Phosphatidylcholine transfer protein (PCTP)
Homo sapiens — UniProt Q9UKL6
Data last refreshed: (UniProt release unknown)
Key facts
Phosphatidylcholine transfer protein (PCTP) is a protein from Homo sapiens identified by UniProt accession Q9UKL6, 214 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.
- UniProt accession: Q9UKL6; gene symbol PCTP.
- Organism: Homo sapiens.
- Length: 214 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lean body mass and appendicular lean mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phosphatidylcholine transfer protein |
|---|---|
| UniProt accession | Q9UKL6 |
| Gene | PCTP |
| Organism | Homo sapiens |
| Length | 214 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (89)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- lean body mass · score 0.30
- appendicular lean mass · score 0.30
- fat body mass · score 0.22
- whole body water mass · score 0.19
- BMI-adjusted waist-hip ratio · score 0.14
- waist-hip ratio · score 0.09
- gallbladder disease · score 0.06
- low phospholipid associated cholelithiasis · score 0.05
- progressive familial intrahepatic cholestasis · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKL6-F1 | alphafold | PREDICTED | 93.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKL6.
Amino-acid sequence (214 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCTP?
The strongest Open Targets associations for PCTP are neurodegenerative disease, lean body mass, appendicular lean mass, fat body mass and whole body water mass.
How long is the PCTP protein?
The Homo sapiens PCTP protein (UniProt Q9UKL6) is 214 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKL6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKL6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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