Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (MAN1B1)
Homo sapiens — UniProt Q9UKM7
Data last refreshed: (UniProt release unknown)
Key facts
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (MAN1B1) is a protein from Homo sapiens identified by UniProt accession Q9UKM7, 699 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q9UKM7; gene symbol MAN1B1.
- Organism: Homo sapiens.
- Length: 699 amino acids.
- Top disease associations (Open Targets): Rafiq syndrome, autosomal recessive non-syndromic intellectual disability and X-linked non-syndromic intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase |
|---|---|
| UniProt accession | Q9UKM7 |
| Gene | MAN1B1 |
| Organism | Homo sapiens |
| Length | 699 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- Rafiq syndrome · score 0.74
- autosomal recessive non-syndromic intellectual disability · score 0.58
- X-linked non-syndromic intellectual disability · score 0.53
- genetic disorder · score 0.50
- MAN1B1-congenital disorder of glycosylation · score 0.46
- COVID-19 · score 0.37
- Global developmental delay · score 0.34
- blood protein measurement · score 0.25
- neurodegenerative disease · score 0.22
- platelet count · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKM7-F1 | alphafold | PREDICTED | 80.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKM7.
Amino-acid sequence (699 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MAN1B1?
The strongest Open Targets associations for MAN1B1 are Rafiq syndrome, autosomal recessive non-syndromic intellectual disability, X-linked non-syndromic intellectual disability, genetic disorder and MAN1B1-congenital disorder of glycosylation.
How long is the MAN1B1 protein?
The Homo sapiens MAN1B1 protein (UniProt Q9UKM7) is 699 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKM7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKM7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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