Mucin-12 (MUC12)
Homo sapiens — UniProt Q9UKN1
Gene: MUC12Homo sapiensSwissProt reviewed
Data last refreshed: (UniProt release unknown)
Key facts
Mucin-12 (MUC12) is a protein from Homo sapiens identified by UniProt accession Q9UKN1, 5478 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.
- UniProt accession: Q9UKN1; gene symbol MUC12.
- Organism: Homo sapiens.
- Length: 5478 amino acids.
- Top disease associations (Open Targets): gut microbiome measurement, hemorrhoid and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mucin-12 |
|---|---|
| UniProt accession | Q9UKN1 |
| Gene | MUC12 |
| Organism | Homo sapiens |
| Length | 5478 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (60)
Diseases linked to this target (Open Targets).
- gut microbiome measurement · score 0.33
- hemorrhoid · score 0.31
- neurodegenerative disease · score 0.29
- lung adenocarcinoma · score 0.27
- breast adenocarcinoma · score 0.26
- endometrial cancer · score 0.25
- bowel opening frequency · score 0.24
- Venous thrombosis · score 0.21
- low density lipoprotein cholesterol measurement · score 0.10
- renal cell carcinoma · score 0.09
3D Structure (10)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKN1-F22 | alphafold | PREDICTED | 46.66 | — |
| AF-Q9UKN1-F21 | alphafold | PREDICTED | 43.53 | — |
| AF-Q9UKN1-F7 | alphafold | PREDICTED | 34.58 | — |
| AF-Q9UKN1-F20 | alphafold | PREDICTED | 34.55 | — |
| AF-Q9UKN1-F9 | alphafold | PREDICTED | 34.43 | — |
| AF-Q9UKN1-F12 | alphafold | PREDICTED | 34.32 | — |
| AF-Q9UKN1-F3 | alphafold | PREDICTED | 34.29 | — |
| AF-Q9UKN1-F2 | alphafold | PREDICTED | 34.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKN1.
Amino-acid sequence (5478 residues)
MLVIWILTLA LRLCASVTTV TPEGSAVHKA ISQQGTLWTG EVLEKQTVEQ GKSTLRRQKN HFHRSAGELR CRNALKDEGA SAGWSVMFAG ESVVVLVHLW MTGARVKNLG LVEFASPGDD GDGRAEGFSL GLPLSEQARA AGAREKERQE TVINHSTFSG FSQITGSTVN TSIGGNTTSA STPSSSDPFT TFSDYGVSVT FITGSTATKH FLDSSTNSGH SEESTVSHSG PGATGTTLFP SHSATSVFVG EPKTSPITSA SMETTALPGS TTTAGLSEKS TTFYSSPRSP DRTLSPARTT SSGVSEKSTT SHSRPGPTHT IAFPDSTTMP GVSQESTASH SIPGSTDTTL SPGTTTPSSL GPESTTFHSS PGYTKTTRLP DNTTTSGLLE ASTPVHSSTG SPHTTLSPSS STTHEGEPTT FQSWPSSKDT SPAPSGTTSA FVKLSTTYHS SPSSTPTTHF SASSTTLGHS EESTPVHSSP VATATTPPPA RSATSGHVEE STAYHRSPGS TQTMHFPESS TTSGHSEESA TFHGSTTHTK SSTPSTTAAL AHTSYHSSLG STETTHFRDS STISGRSEES KASHSSPDAM ATTVLPAGST PSVLVGDSTP SPISSGSMET TALPGSTTKP GLSEKSTTFY SSPRSPDTTH LPASMTSSGV SEESTTSHSR PGSTHTTAFP GSTTMPGLSQ ESTASHSSPG PTDTTLSPGS TTASSLGPEY TTFHSRPGST ETTLLPDNTT ASGLLEASMP VHSSTRSPHT TLSPAGSTTR QGESTTFHSW PSSKDTRPAP PTTTSAFVEP STTSHGSPSS IPTTHISARS TTSGLVEEST TYHSSPGSTQ TMHFPESDTT SGRGEESTTS HSSTTHTISS APSTTSALVE EPTSYHSSPG STATTHFPDS STTSGRSEES TASHSSQDAT GTIVLPARST TSVLLGESTT SPISSGSMET TALPGSTTTP GLSERSTTFH SSPRSPATTL SPASTTSSGV SEESTTSRSR PGSTHTTAFP DSTTTPGLSR HSTTSHSSPG STDTTLLPAS TTTSGPSQES TTSHSSSGST DTALSPGSTT ALSFGQESTT FHSNPGSTHT TLFPDSTTSS GIVEASTRVH SSTGSPRTTL SPASSTSPGL QGESTAFQTH PASTHTTPSP PSTATAPVEE STTYHRSPGS TPTTHFPASS TTSGHSEKST IFHSSPDASG TTPSSAHSTT SGRGESTTSR ISPGSTEITT LPGSTTTPGL SEASTTFYSS PRSPTTTLSP ASMTSLGVGE ESTTSRSQPG STHSTVSPAS TTTPGLSEES TTVYSSSRGS TETTVFPHST TTSVHGEEPT TFHSRPASTH TTLFTEDSTT SGLTEESTAF PGSPASTQTG LPATLTTADL GEESTTFPSS SGSTGTKLSP ARSTTSGLVG ESTPSRLSPS STETTTLPGS PTTPSLSEKS TTFYTSPRSP DATLSPATTT SSGVSEESST SHSQPGSTHT TAFPDSTTTS DLSQEPTTSH SSQGSTEATL SPGSTTASSL GQQSTTFHSS PGDTETTLLP DDTITSGLVE ASTPTHSSTG SLHTTLTPAS STSAGLQEES TTFQSWPSSS DTTPSPPGTT AAPVEVSTTY HSRPSSTPTT HFSASSTTLG RSEESTTVHS SPGATGTALF PTRSATSVLV GEPTTSPISS GSTETTALPG STTTAGLSEK STTFYSSPRS PDTTLSPAST TSSGVSEEST TSHSRPGSTH TTAFPGSTTM PGVSQESTAS HSSPGSTDTT LSPGSTTASS LGPESTTFHS SPGSTETTLL PDNTTASGLL EASTPVHSST GSPHTTLSPA GSTTRQGEST TFQSWPSSKD TMPAPPTTTS AFVELSTTSH GSPSSTPTTH FSASSTTLGR SEESTTVHSS PVATATTPSP ARSTTSGLVE ESTAYHSSPG STQTMHFPES STASGRSEES RTSHSSTTHT ISSPPSTTSA LVEEPTSYHS SPGSTATTHF PDSSTTSGRS EESTASHSSQ DATGTIVLPA RSTTSVLLGE STTSPISSGS METTALPGST TTPGLSEKST TFHSSPRSPA TTLSPASTTS SGVSEESTTS HSRPGSTHTT AFPDSTTTPG LSRHSTTSHS SPGSTDTTLL PASTTTSGPS QESTTSHSSP GSTDTALSPG STTALSFGQE STTFHSSPGS THTTLFPDST TSSGIVEAST RVHSSTGSPR TTLSPASSTS PGLQGESTAF QTHPASTHTT PSPPSTATAP VEESTTYHRS PGSTPTTHFP ASSTTSGHSE KSTIFHSSPD ASGTTPSSAH STTSGRGEST TSRISPGSTE ITTLPGSTTT PGLSEASTTF YSSPRSPTTT LSPASMTSLG VGEESTTSRS QPGSTHSTVS PASTTTPGLS EESTTVYSSS PGSTETTVFP RTPTTSVRGE EPTTFHSRPA STHTTLFTED STTSGLTEES TAFPGSPAST QTGLPATLTT ADLGEESTTF PSSSGSTGTT LSPARSTTSG LVGESTPSRL SPSSTETTTL PGSPTTPSLS EKSTTFYTSP RSPDATLSPA TTTSSGVSEE SSTSHSQPGS THTTAFPDST TTPGLSRHST TSHSSPGSTD TTLLPASTTT SGPSQESTTS HSSPGSTDTA LSPGSTTALS FGQESTTFHS SPGSTHTTLF PDSTTSSGIV EASTRVHSST GSPRTTLSPA SSTSPGLQGE STTFQTHPAS THTTPSPPST ATAPVEESTT YHRSPGSTPT THFPASSTTS GHSEKSTIFH SSPDASGTTP SSAHSTTSGR GESTTSRISP GSTEITTLPG STTTPGLSEA STTFYSSPRS PTTTLSPASM TSLGVGEEST TSRSQPGSTH STVSPASTTT PGLSEESTTV YSSSPGSTET TVFPRSTTTS VRGEEPTTFH SRPASTHTTL FTEDSTTSGL TEESTAFPGS PASTQTGLPA TLTTADLGEE STTFPSSSGS TGTTLSPARS TTSGLVGEST PSRLSPSSTE TTTLPGSPTT PSLSEKSTTF YTSPRSPDAT LSPATTTSSG VSEESSTSHS QPGSTHTTAF PDSTTTSGLS QEPTASHSSQ GSTEATLSPG STTASSLGQQ STTFHSSPGD TETTLLPDDT ITSGLVEAST PTHSSTGSLH TTLTPASSTS AGLQEESTTF QSWPSSSDTT PSPPGTTAAP VEVSTTYHSR PSSTPTTHFS ASSTTLGRSE ESTTVHSSPG ATGTALFPTR SATSVLVGEP TTSPISSGST ETTALPGSTT TAGLSEKSTT FYSSPRSPDT TLSPASTTSS GVSEESTTSH SRPGSTHTTA FPGSTTMPGV SQESTASHSS PGSTDTTLSP GSTTASSLGP ESTTFHSGPG STETTLLPDN TTASGLLEAS TPVHSSTGSP HTTLSPAGST TRQGESTTFQ SWPNSKDTTP APPTTTSAFV ELSTTSHGSP SSTPTTHFSA SSTTLGRSEE STTVHSSPVA TATTPSPARS TTSGLVEEST TYHSSPGSTQ TMHFPESDTT SGRGEESTTS HSSTTHTISS APSTTSALVE EPTSYHSSPG STATTHFPDS STTSGRSEES TASHSSQDAT GTIVLPARST TSVLLGESTT SPISSGSMET TALPGSTTTP GLSEKSTTFH SSPRSPATTL SPASTTSSGV SEESTTSHSR PGSTHTTAFP DSTTTPGLSR HSTTSHSSPG STDTTLLPAS TTTSGSSQES TTSHSSSGST DTALSPGSTT ALSFGQESTT FHSSPGSTHT TLFPDSTTSS GIVEASTRVH SSTGSPRTTL SPASSTSPGL QGESTAFQTH PASTHTTPSP PSTATAPVEE STTYHRSPGS TPTTHFPASS TTSGHSEKST IFHSSPDASG TTPSSAHSTT SGRGESTTSR ISPGSTEITT LPGSTTTPGL SEASTTFYSS PRSPTTTLSP ASMTSLGVGE ESTTSRSQPG STHSTVSPAS TTTPGLSEES TTVYSSSPGS TETTVFPRST TTSVRREEPT TFHSRPASTH TTLFTEDSTT SGLTEESTAF PGSPASTQTG LPATLTTADL GEESTTFPSS SGSTGTKLSP ARSTTSGLVG ESTPSRLSPS STETTTLPGS PTTPSLSEKS TTFYTSPRSP DATLSPATTT SSGVSEESST SHSQPGSTHT TAFPDSTTTS GLSQEPTTSH SSQGSTEATL SPGSTTASSL GQQSTTFHSS PGDTETTLLP DDTITSGLVE ASTPTHSSTG SLHTTLTPAS STSTGLQEES TTFQSWPSSS DTTPSPPSTT AVPVEVSTTY HSRPSSTPTT HFSASSTTLG RSEESTTVHS SPGATGTALF PTRSATSVLV GEPTTSPISS GSTETTALPG STTTAGLSEK STTFYSSPRS PDTTLSPAST TSSGVSEEST TSHSRPGSMH TTAFPSSTTM PGVSQESTAS HSSPGSTDTT LSPGSTTASS LGPESTTFHS SPGSTETTLL PDNTTASGLL EASTPVHSST GSPHTTLSPA GSTTRQGEST TFQSWPNSKD TTPAPPTTTS AFVELSTTSH GSPSSTPTTH FSASSTTLGR SEESTTVHSS PVATATTPSP ARSTTSGLVE ESTTYHSSPG STQTMHFPES NTTSGRGEES TTSHSSTTHT ISSAPSTTSA LVEEPTSYHS SPGSTATTHF PDSSTTSGRS EESTASHSSQ DATGTIVLPA RSTTSVLLGE STTSPISSGS METTALPGST TTPGLSEKST TFHSSPSSTP TTHFSASSTT LGRSEESTTV HSSPVATATT PSPARSTTSG LVEESTAYHS SPGSTQTMHF PESSTASGRS EESRTSHSST THTISSPPST TSALVEEPTS YHSSPGSIAT THFPESSTTS GRSEESTASH SSPDTNGITP LPAHFTTSGR IAESTTFYIS PGSMETTLAS TATTPGLSAK STILYSSSRS PDQTLSPASM TSSSISGEPT SLYSQAESTH TTAFPASTTT SGLSQESTTF HSKPGSTETT LSPGSITTSS FAQEFTTPHS QPGSALSTVS PASTTVPGLS EESTTFYSSP GSTETTAFSH SNTMSIHSQQ STPFPDSPGF THTVLPATLT TTDIGQESTA FHSSSDATGT TPLPARSTAS DLVGEPTTFY ISPSPTYTTL FPASSSTSGL TEESTTFHTS PSFTSTIVST ESLETLAPGL CQEGQIWNGK QCVCPQGYVG YQCLSPLESF PVETPEKLNA TLGMTVKVTY RNFTEKMNDA SSQEYQNFST LFKNRMDVVL KGDNLPQYRG VNIRRLLNGS IVVKNDVILE ADYTLEYEEL FENLAEIVKA KIMNETRTTL LDPDSCRKAI LCYSEEDTFV DSSVTPGFDF QEQCTQKAAE GYTQFYYVDV LDGKLACVNK CTKGTKSQMN CNLGTCQLQR SGPRCLCPNT NTHWYWGETC EFNIAKSLVY GIVGAVMAVL LLALIILIIL FSLSQRKRHR EQYDVPQEWR KEGTPGIFQK TAIWEDQNLR ESRFGLENAY NNFRPTLETV DSGTELHIQR PEMVASTV
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MUC12?
The strongest Open Targets associations for MUC12 are gut microbiome measurement, hemorrhoid, neurodegenerative disease, lung adenocarcinoma and breast adenocarcinoma.
How long is the MUC12 protein?
The Homo sapiens MUC12 protein (UniProt Q9UKN1) is 5478 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKN1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKN1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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