General transcription factor 3C polypeptide 4 (GTF3C4)
Homo sapiens — UniProt Q9UKN8
Data last refreshed: (UniProt release unknown)
Key facts
General transcription factor 3C polypeptide 4 (GTF3C4) is a protein from Homo sapiens identified by UniProt accession Q9UKN8, 822 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.
- UniProt accession: Q9UKN8; gene symbol GTF3C4.
- Organism: Homo sapiens.
- Length: 822 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, platelet component distribution width and self reported educational attainment.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | General transcription factor 3C polypeptide 4 |
|---|---|
| UniProt accession | Q9UKN8 |
| Gene | GTF3C4 |
| Organism | Homo sapiens |
| Length | 822 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (17)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.29
- platelet component distribution width · score 0.28
- self reported educational attainment · score 0.10
- age at menopause · score 0.08
- angiopoietin-1 receptor measurement · score 0.06
- neurofibrillary tangles measurement · score 0.05
- erythrocyte count · score 0.05
- mean corpuscular hemoglobin concentration · score 0.02
- mean corpuscular volume · score 0.02
- mean reticulocyte volume · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKN8-F1 | alphafold | PREDICTED | 81.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKN8.
Amino-acid sequence (822 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GTF3C4?
The strongest Open Targets associations for GTF3C4 are neurodegenerative disease, platelet component distribution width, self reported educational attainment, age at menopause and angiopoietin-1 receptor measurement.
How long is the GTF3C4 protein?
The Homo sapiens GTF3C4 protein (UniProt Q9UKN8) is 822 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKN8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKN8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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