A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAMTS6)
Homo sapiens — UniProt Q9UKP5
Data last refreshed: (UniProt release unknown)
Key facts
A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAMTS6) is a protein from Homo sapiens identified by UniProt accession Q9UKP5, 1117 residues long. MolForge cross-references it against 0 known binders and 233 disease associations.
- UniProt accession: Q9UKP5; gene symbol ADAMTS6.
- Organism: Homo sapiens.
- Length: 1117 amino acids.
- Top disease associations (Open Targets): body height, BMI-adjusted waist circumference and intraocular pressure measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | A disintegrin and metalloproteinase with thrombospondin motifs 6 |
|---|---|
| UniProt accession | Q9UKP5 |
| Gene | ADAMTS6 |
| Organism | Homo sapiens |
| Length | 1117 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (233)
Diseases linked to this target (Open Targets).
- body height · score 0.66
- BMI-adjusted waist circumference · score 0.50
- intraocular pressure measurement · score 0.44
- central corneal thickness · score 0.43
- BMI-adjusted waist-hip ratio · score 0.40
- appendicular lean mass · score 0.39
- vital capacity · score 0.34
- corneal topography · score 0.32
- adolescent idiopathic scoliosis · score 0.30
- brain measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKP5-F1 | alphafold | PREDICTED | 77.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKP5.
Amino-acid sequence (1117 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADAMTS6?
The strongest Open Targets associations for ADAMTS6 are body height, BMI-adjusted waist circumference, intraocular pressure measurement, central corneal thickness and BMI-adjusted waist-hip ratio.
How long is the ADAMTS6 protein?
The Homo sapiens ADAMTS6 protein (UniProt Q9UKP5) is 1117 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKP5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKP5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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