Kallikrein-12 (KLK12)
Homo sapiens — UniProt Q9UKR0
Data last refreshed: (UniProt release unknown)
Key facts
Kallikrein-12 (KLK12) is a protein from Homo sapiens identified by UniProt accession Q9UKR0, 248 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.
- UniProt accession: Q9UKR0; gene symbol KLK12.
- Organism: Homo sapiens.
- Length: 248 amino acids.
- Top disease associations (Open Targets): blood protein measurement, protein measurement and kallikrein-12 measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kallikrein-12 |
|---|---|
| UniProt accession | Q9UKR0 |
| Gene | KLK12 |
| Organism | Homo sapiens |
| Length | 248 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (43)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.27
- protein measurement · score 0.23
- kallikrein-12 measurement · score 0.14
- urinary bladder cancer · score 0.11
- squamous cell lung carcinoma · score 0.11
- endometrial cancer · score 0.10
- triple-negative breast cancer · score 0.06
- breast carcinoma · score 0.05
- neoplasm · score 0.04
- non-small cell lung carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKR0-F1 | alphafold | PREDICTED | 88.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKR0.
Amino-acid sequence (248 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KLK12?
The strongest Open Targets associations for KLK12 are blood protein measurement, protein measurement, kallikrein-12 measurement, urinary bladder cancer and squamous cell lung carcinoma.
How long is the KLK12 protein?
The Homo sapiens KLK12 protein (UniProt Q9UKR0) is 248 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKR0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKR0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.