Protein kinase C and casein kinase substrate in neurons protein 3 (PACSIN3)
Homo sapiens — UniProt Q9UKS6
Data last refreshed: (UniProt release unknown)
Key facts
Protein kinase C and casein kinase substrate in neurons protein 3 (PACSIN3) is a protein from Homo sapiens identified by UniProt accession Q9UKS6, 424 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.
- UniProt accession: Q9UKS6; gene symbol PACSIN3.
- Organism: Homo sapiens.
- Length: 424 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, heel bone mineral density and reticulocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein kinase C and casein kinase substrate in neurons protein 3 |
|---|---|
| UniProt accession | Q9UKS6 |
| Gene | PACSIN3 |
| Organism | Homo sapiens |
| Length | 424 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (62)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.19
- heel bone mineral density · score 0.08
- reticulocyte count · score 0.08
- platelet count · score 0.07
- lymphocyte count · score 0.07
- self reported educational attainment · score 0.06
- BMI-adjusted hip circumference · score 0.05
- bone quantitative ultrasound measurement · score 0.05
- bone density · score 0.05
- protein measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKS6-F1 | alphafold | PREDICTED | 86.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKS6.
Amino-acid sequence (424 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PACSIN3?
The strongest Open Targets associations for PACSIN3 are neurodegenerative disease, heel bone mineral density, reticulocyte count, platelet count and lymphocyte count.
How long is the PACSIN3 protein?
The Homo sapiens PACSIN3 protein (UniProt Q9UKS6) is 424 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKS6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKS6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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