Zinc finger protein Helios (IKZF2)
Homo sapiens — UniProt Q9UKS7
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein Helios (IKZF2) is a protein from Homo sapiens identified by UniProt accession Q9UKS7, 526 residues long. MolForge cross-references it against 0 known binders and 258 disease associations.
- UniProt accession: Q9UKS7; gene symbol IKZF2.
- Organism: Homo sapiens.
- Length: 526 amino acids.
- Top disease associations (Open Targets): eosinophil count, eosinophil percentage of leukocytes and systemic lupus erythematosus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein Helios |
|---|---|
| UniProt accession | Q9UKS7 |
| Gene | IKZF2 |
| Organism | Homo sapiens |
| Length | 526 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (258)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.49
- eosinophil percentage of leukocytes · score 0.48
- systemic lupus erythematosus · score 0.44
- C-reactive protein measurement · score 0.43
- basophil count · score 0.42
- lymphocyte count · score 0.38
- neurodegenerative disease · score 0.38
- sum of eosinophil and basophil counts · score 0.38
- neutrophil percentage of granulocytes · score 0.37
- eosinophil percentage of granulocytes · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKS7-F1 | alphafold | PREDICTED | 52.44 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKS7.
Amino-acid sequence (526 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IKZF2?
The strongest Open Targets associations for IKZF2 are eosinophil count, eosinophil percentage of leukocytes, systemic lupus erythematosus, C-reactive protein measurement and basophil count.
How long is the IKZF2 protein?
The Homo sapiens IKZF2 protein (UniProt Q9UKS7) is 526 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKS7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKS7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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