F-box only protein 5 (FBXO5)
Homo sapiens — UniProt Q9UKT4
Data last refreshed: (UniProt release unknown)
Key facts
F-box only protein 5 (FBXO5) is a protein from Homo sapiens identified by UniProt accession Q9UKT4, 447 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.
- UniProt accession: Q9UKT4; gene symbol FBXO5.
- Organism: Homo sapiens.
- Length: 447 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, monocyte percentage of leukocytes and endometrial cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-box only protein 5 |
|---|---|
| UniProt accession | Q9UKT4 |
| Gene | FBXO5 |
| Organism | Homo sapiens |
| Length | 447 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (87)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- monocyte percentage of leukocytes · score 0.28
- endometrial cancer · score 0.24
- chronotype measurement · score 0.18
- lysosomal storage disease · score 0.13
- neoplasm · score 0.10
- esophageal squamous cell carcinoma · score 0.09
- cancer · score 0.08
- breast cancer · score 0.08
- neutrophil count · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKT4-F1 | alphafold | PREDICTED | 59.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKT4.
Amino-acid sequence (447 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FBXO5?
The strongest Open Targets associations for FBXO5 are neurodegenerative disease, monocyte percentage of leukocytes, endometrial cancer, chronotype measurement and lysosomal storage disease.
How long is the FBXO5 protein?
The Homo sapiens FBXO5 protein (UniProt Q9UKT4) is 447 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKT4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKT4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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