F-box only protein 4 (FBXO4)
Homo sapiens — UniProt Q9UKT5
Data last refreshed: (UniProt release unknown)
Key facts
F-box only protein 4 (FBXO4) is a protein from Homo sapiens identified by UniProt accession Q9UKT5, 387 residues long. MolForge cross-references it against 0 known binders and 98 disease associations.
- UniProt accession: Q9UKT5; gene symbol FBXO4.
- Organism: Homo sapiens.
- Length: 387 amino acids.
- Top disease associations (Open Targets): head and neck squamous cell carcinoma, endometrial cancer and lung adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-box only protein 4 |
|---|---|
| UniProt accession | Q9UKT5 |
| Gene | FBXO4 |
| Organism | Homo sapiens |
| Length | 387 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (98)
Diseases linked to this target (Open Targets).
- head and neck squamous cell carcinoma · score 0.26
- endometrial cancer · score 0.25
- lung adenocarcinoma · score 0.25
- gastric adenocarcinoma · score 0.25
- breast adenocarcinoma · score 0.25
- urinary bladder cancer · score 0.24
- Ketonuria · score 0.20
- squamous cell lung carcinoma · score 0.18
- clear cell renal carcinoma · score 0.18
- hepatocellular carcinoma · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKT5-F1 | alphafold | PREDICTED | 78.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKT5.
Amino-acid sequence (387 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FBXO4?
The strongest Open Targets associations for FBXO4 are head and neck squamous cell carcinoma, endometrial cancer, lung adenocarcinoma, gastric adenocarcinoma and breast adenocarcinoma.
How long is the FBXO4 protein?
The Homo sapiens FBXO4 protein (UniProt Q9UKT5) is 387 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKT5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKT5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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