F-box/LRR-repeat protein 3 (FBXL3)
Homo sapiens — UniProt Q9UKT7
Data last refreshed: (UniProt release unknown)
Key facts
F-box/LRR-repeat protein 3 (FBXL3) is a protein from Homo sapiens identified by UniProt accession Q9UKT7, 428 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.
- UniProt accession: Q9UKT7; gene symbol FBXL3.
- Organism: Homo sapiens.
- Length: 428 amino acids.
- Top disease associations (Open Targets): intellectual disability, short stature, facial anomalies, and joint dislocations, Intellectual disability and Short stature.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-box/LRR-repeat protein 3 |
|---|---|
| UniProt accession | Q9UKT7 |
| Gene | FBXL3 |
| Organism | Homo sapiens |
| Length | 428 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (49)
Diseases linked to this target (Open Targets).
- intellectual disability, short stature, facial anomalies, and joint dislocations · score 0.64
- Intellectual disability · score 0.37
- Short stature · score 0.37
- chronotype measurement · score 0.25
- endometrial cancer · score 0.25
- lung adenocarcinoma · score 0.25
- esophageal cancer · score 0.25
- gastric adenocarcinoma · score 0.25
- breast adenocarcinoma · score 0.25
- PHF-tau measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKT7-F1 | alphafold | PREDICTED | 90.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKT7.
Amino-acid sequence (428 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FBXL3?
The strongest Open Targets associations for FBXL3 are intellectual disability, short stature, facial anomalies, and joint dislocations, Intellectual disability, Short stature, chronotype measurement and endometrial cancer.
How long is the FBXL3 protein?
The Homo sapiens FBXL3 protein (UniProt Q9UKT7) is 428 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKT7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKT7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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