F-box/WD repeat-containing protein 2 (FBXW2)
Homo sapiens — UniProt Q9UKT8
Data last refreshed: (UniProt release unknown)
Key facts
F-box/WD repeat-containing protein 2 (FBXW2) is a protein from Homo sapiens identified by UniProt accession Q9UKT8, 454 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.
- UniProt accession: Q9UKT8; gene symbol FBXW2.
- Organism: Homo sapiens.
- Length: 454 amino acids.
- Top disease associations (Open Targets): ovarian cancer, endometrial cancer and lung adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-box/WD repeat-containing protein 2 |
|---|---|
| UniProt accession | Q9UKT8 |
| Gene | FBXW2 |
| Organism | Homo sapiens |
| Length | 454 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (57)
Diseases linked to this target (Open Targets).
- ovarian cancer · score 0.25
- endometrial cancer · score 0.25
- lung adenocarcinoma · score 0.25
- esophageal cancer · score 0.25
- gastric adenocarcinoma · score 0.25
- breast adenocarcinoma · score 0.25
- protein measurement · score 0.19
- chronic lymphocytic leukemia · score 0.14
- sex hormone-binding globulin measurement · score 0.12
- platelet count · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKT8-F1 | alphafold | PREDICTED | 89.12 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKT8.
Amino-acid sequence (454 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FBXW2?
The strongest Open Targets associations for FBXW2 are ovarian cancer, endometrial cancer, lung adenocarcinoma, esophageal cancer and gastric adenocarcinoma.
How long is the FBXW2 protein?
The Homo sapiens FBXW2 protein (UniProt Q9UKT8) is 454 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKT8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKT8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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