Long-chain-fatty-acid--CoA ligase 6 (ACSL6)
Homo sapiens — UniProt Q9UKU0
Data last refreshed: (UniProt release unknown)
Key facts
Long-chain-fatty-acid--CoA ligase 6 (ACSL6) is a protein from Homo sapiens identified by UniProt accession Q9UKU0, 697 residues long. MolForge cross-references it against 0 known binders and 183 disease associations.
- UniProt accession: Q9UKU0; gene symbol ACSL6.
- Organism: Homo sapiens.
- Length: 697 amino acids.
- Top disease associations (Open Targets): apolipoprotein A 1 measurement, melanoma and calcium measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Long-chain-fatty-acid--CoA ligase 6 |
|---|---|
| UniProt accession | Q9UKU0 |
| Gene | ACSL6 |
| Organism | Homo sapiens |
| Length | 697 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (183)
Diseases linked to this target (Open Targets).
- apolipoprotein A 1 measurement · score 0.31
- melanoma · score 0.22
- calcium measurement · score 0.21
- osteosarcoma · score 0.19
- acute myeloid leukemia · score 0.19
- colorectal adenocarcinoma · score 0.19
- hepatocellular carcinoma · score 0.19
- esophageal squamous cell carcinoma · score 0.19
- gastric carcinoma · score 0.19
- oral squamous cell carcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKU0-F1 | alphafold | PREDICTED | 90.07 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKU0.
Amino-acid sequence (697 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ACSL6?
The strongest Open Targets associations for ACSL6 are apolipoprotein A 1 measurement, melanoma, calcium measurement, osteosarcoma and acute myeloid leukemia.
How long is the ACSL6 protein?
The Homo sapiens ACSL6 protein (UniProt Q9UKU0) is 697 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKU0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKU0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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