Isobutyryl-CoA dehydrogenase, mitochondrial (ACAD8)
Homo sapiens — UniProt Q9UKU7
Data last refreshed: (UniProt release unknown)
Key facts
Isobutyryl-CoA dehydrogenase, mitochondrial (ACAD8) is a protein from Homo sapiens identified by UniProt accession Q9UKU7, 415 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.
- UniProt accession: Q9UKU7; gene symbol ACAD8.
- Organism: Homo sapiens.
- Length: 415 amino acids.
- Top disease associations (Open Targets): isobutyryl-CoA dehydrogenase deficiency, genetic disorder and neuroinflammatory disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Isobutyryl-CoA dehydrogenase, mitochondrial |
|---|---|
| UniProt accession | Q9UKU7 |
| Gene | ACAD8 |
| Organism | Homo sapiens |
| Length | 415 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (59)
Diseases linked to this target (Open Targets).
- isobutyryl-CoA dehydrogenase deficiency · score 0.80
- genetic disorder · score 0.47
- neuroinflammatory disorder · score 0.26
- blood protein measurement · score 0.18
- metabolite measurement · score 0.16
- body mass index · score 0.05
- schizophrenia · score 0.05
- body fat percentage · score 0.05
- alkaline phosphatase measurement · score 0.04
- body weight · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKU7-F1 | alphafold | PREDICTED | 94.18 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKU7.
Amino-acid sequence (415 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ACAD8?
The strongest Open Targets associations for ACAD8 are isobutyryl-CoA dehydrogenase deficiency, genetic disorder, neuroinflammatory disorder, blood protein measurement and metabolite measurement.
How long is the ACAD8 protein?
The Homo sapiens ACAD8 protein (UniProt Q9UKU7) is 415 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKU7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKU7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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