Angiopoietin-related protein 2 (ANGPTL2)
Homo sapiens — UniProt Q9UKU9
Data last refreshed: (UniProt release unknown)
Key facts
Angiopoietin-related protein 2 (ANGPTL2) is a protein from Homo sapiens identified by UniProt accession Q9UKU9, 493 residues long. MolForge cross-references it against 0 known binders and 227 disease associations.
- UniProt accession: Q9UKU9; gene symbol ANGPTL2.
- Organism: Homo sapiens.
- Length: 493 amino acids.
- Top disease associations (Open Targets): body height, Abnormality of the skeletal system and forced expiratory volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Angiopoietin-related protein 2 |
|---|---|
| UniProt accession | Q9UKU9 |
| Gene | ANGPTL2 |
| Organism | Homo sapiens |
| Length | 493 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (227)
Diseases linked to this target (Open Targets).
- body height · score 0.57
- Abnormality of the skeletal system · score 0.22
- forced expiratory volume · score 0.21
- sitting height measurement · score 0.20
- intraocular pressure measurement · score 0.14
- body fat percentage · score 0.13
- DNA methylation · score 0.13
- appendicular lean mass · score 0.11
- neoplasm · score 0.11
- glaucoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKU9-F1 | alphafold | PREDICTED | 78.21 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKU9.
Amino-acid sequence (493 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ANGPTL2?
The strongest Open Targets associations for ANGPTL2 are body height, Abnormality of the skeletal system, forced expiratory volume, sitting height measurement and intraocular pressure measurement.
How long is the ANGPTL2 protein?
The Homo sapiens ANGPTL2 protein (UniProt Q9UKU9) is 493 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKU9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKU9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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