Histone deacetylase 9 (HDAC9)
Homo sapiens — UniProt Q9UKV0
Data last refreshed: (UniProt release unknown)
Key facts
Histone deacetylase 9 (HDAC9) is a protein from Homo sapiens identified by UniProt accession Q9UKV0, 1011 residues long. MolForge cross-references it against 5 known binders and 1,020 disease associations.
- UniProt accession: Q9UKV0; gene symbol HDAC9.
- Organism: Homo sapiens.
- Length: 1011 amino acids.
- Approved drugs acting on it (DrugCentral): Panobinostat, Belinostat, Givinostat and Romidepsin.
- Top disease associations (Open Targets): multiple myeloma, neoplasm and unspecified peripheral T-cell lymphoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Histone deacetylase 9 |
|---|---|
| UniProt accession | Q9UKV0 |
| Gene | HDAC9 |
| Organism | Homo sapiens |
| Length | 1011 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (4)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (1020)
Diseases linked to this target (Open Targets).
- multiple myeloma · score 0.56
- neoplasm · score 0.55
- unspecified peripheral T-cell lymphoma · score 0.52
- T-cell non-Hodgkin lymphoma · score 0.48
- platelet count · score 0.46
- vital capacity · score 0.46
- forced expiratory volume · score 0.44
- platelet crit · score 0.43
- Cutaneous T-cell lymphoma · score 0.43
- body height · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKV0-F1 | alphafold | PREDICTED | 64.23 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKV0.
Amino-acid sequence (1011 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target HDAC9?
DrugCentral lists 4 approved drugs whose mechanism of action is HDAC9: Panobinostat, Belinostat, Givinostat and Romidepsin.
Which diseases are associated with HDAC9?
The strongest Open Targets associations for HDAC9 are multiple myeloma, neoplasm, unspecified peripheral T-cell lymphoma, T-cell non-Hodgkin lymphoma and platelet count.
How long is the HDAC9 protein?
The Homo sapiens HDAC9 protein (UniProt Q9UKV0) is 1011 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKV0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKV0 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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