Apoptotic chromatin condensation inducer in the nucleus (ACIN1)
Homo sapiens — UniProt Q9UKV3
Data last refreshed: (UniProt release unknown)
Key facts
Apoptotic chromatin condensation inducer in the nucleus (ACIN1) is a protein from Homo sapiens identified by UniProt accession Q9UKV3, 1341 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q9UKV3; gene symbol ACIN1.
- Organism: Homo sapiens.
- Length: 1341 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, breast adenocarcinoma and ovarian cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Apoptotic chromatin condensation inducer in the nucleus |
|---|---|
| UniProt accession | Q9UKV3 |
| Gene | ACIN1 |
| Organism | Homo sapiens |
| Length | 1341 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- breast adenocarcinoma · score 0.25
- ovarian cancer · score 0.23
- low grade glioma · score 0.23
- endometrial cancer · score 0.23
- glioblastoma multiforme · score 0.23
- esophageal cancer · score 0.15
- mean reticulocyte volume · score 0.15
- Mental deterioration · score 0.14
- head and neck squamous cell carcinoma · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKV3-F1 | alphafold | PREDICTED | 50.62 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKV3.
Amino-acid sequence (1341 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ACIN1?
The strongest Open Targets associations for ACIN1 are neurodegenerative disease, breast adenocarcinoma, ovarian cancer, low grade glioma and endometrial cancer.
How long is the ACIN1 protein?
The Homo sapiens ACIN1 protein (UniProt Q9UKV3) is 1341 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKV3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKV3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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