E3 ubiquitin-protein ligase AMFR (AMFR)
Homo sapiens — UniProt Q9UKV5
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase AMFR (AMFR) is a protein from Homo sapiens identified by UniProt accession Q9UKV5, 643 residues long. MolForge cross-references it against 0 known binders and 204 disease associations.
- UniProt accession: Q9UKV5; gene symbol AMFR.
- Organism: Homo sapiens.
- Length: 643 amino acids.
- Top disease associations (Open Targets): apolipoprotein A 1 measurement, neurodegenerative disease and pancreatic adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase AMFR |
|---|---|
| UniProt accession | Q9UKV5 |
| Gene | AMFR |
| Organism | Homo sapiens |
| Length | 643 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (204)
Diseases linked to this target (Open Targets).
- apolipoprotein A 1 measurement · score 0.25
- neurodegenerative disease · score 0.22
- pancreatic adenocarcinoma · score 0.21
- breast carcinoma · score 0.15
- body mass index · score 0.14
- diastolic blood pressure · score 0.12
- Primary amenorrhea · score 0.12
- urate measurement · score 0.11
- breast ductal adenocarcinoma · score 0.11
- neoplasm · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKV5-F1 | alphafold | PREDICTED | 72.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKV5.
Amino-acid sequence (643 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AMFR?
The strongest Open Targets associations for AMFR are apolipoprotein A 1 measurement, neurodegenerative disease, pancreatic adenocarcinoma, breast carcinoma and body mass index.
How long is the AMFR protein?
The Homo sapiens AMFR protein (UniProt Q9UKV5) is 643 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKV5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKV5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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