Protein argonaute-2 (AGO2)
Homo sapiens — UniProt Q9UKV8
Data last refreshed: (UniProt release unknown)
Key facts
Protein argonaute-2 (AGO2) is a protein from Homo sapiens identified by UniProt accession Q9UKV8, 859 residues long. MolForge cross-references it against 4 known binders and 329 disease associations.
- UniProt accession: Q9UKV8; gene symbol AGO2.
- Organism: Homo sapiens.
- Length: 859 amino acids.
- Top disease associations (Open Targets): Lessel-Kreienkamp syndrome, cancer and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein argonaute-2 |
|---|---|
| UniProt accession | Q9UKV8 |
| Gene | AGO2 |
| Organism | Homo sapiens |
| Length | 859 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (329)
Diseases linked to this target (Open Targets).
- Lessel-Kreienkamp syndrome · score 0.66
- cancer · score 0.49
- mean corpuscular volume · score 0.47
- mean corpuscular hemoglobin · score 0.44
- hypothyroidism · score 0.42
- mean corpuscular hemoglobin concentration · score 0.41
- genetic disorder · score 0.41
- Thyroid preparation use measurement · score 0.39
- thyroid disease · score 0.38
- mean reticulocyte volume · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKV8-F1 | alphafold | PREDICTED | 92.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKV8.
Amino-acid sequence (859 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AGO2?
The strongest Open Targets associations for AGO2 are Lessel-Kreienkamp syndrome, cancer, mean corpuscular volume, mean corpuscular hemoglobin and hypothyroidism.
How long is the AGO2 protein?
The Homo sapiens AGO2 protein (UniProt Q9UKV8) is 859 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKV8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKV8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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