Guanine nucleotide exchange factor VAV3 (VAV3)
Homo sapiens — UniProt Q9UKW4
Data last refreshed: (UniProt release unknown)
Key facts
Guanine nucleotide exchange factor VAV3 (VAV3) is a protein from Homo sapiens identified by UniProt accession Q9UKW4, 847 residues long. MolForge cross-references it against 0 known binders and 184 disease associations.
- UniProt accession: Q9UKW4; gene symbol VAV3.
- Organism: Homo sapiens.
- Length: 847 amino acids.
- Top disease associations (Open Targets): cutaneous Leishmaniasis, hypothyroidism and Hashimoto's thyroiditis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Guanine nucleotide exchange factor VAV3 |
|---|---|
| UniProt accession | Q9UKW4 |
| Gene | VAV3 |
| Organism | Homo sapiens |
| Length | 847 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (184)
Diseases linked to this target (Open Targets).
- cutaneous Leishmaniasis · score 0.50
- hypothyroidism · score 0.48
- Hashimoto's thyroiditis · score 0.43
- eosinophil count · score 0.40
- neutrophil count · score 0.39
- neurodegenerative disease · score 0.39
- Thyroid preparation use measurement · score 0.38
- thyroid disease · score 0.38
- drug use measurement · score 0.38
- autoimmune disease · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKW4-F1 | alphafold | PREDICTED | 84.87 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKW4.
Amino-acid sequence (847 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VAV3?
The strongest Open Targets associations for VAV3 are cutaneous Leishmaniasis, hypothyroidism, Hashimoto's thyroiditis, eosinophil count and neutrophil count.
How long is the VAV3 protein?
The Homo sapiens VAV3 protein (UniProt Q9UKW4) is 847 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKW4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKW4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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