Zinc fingers and homeoboxes protein 1 (ZHX1)
Homo sapiens — UniProt Q9UKY1
Data last refreshed: (UniProt release unknown)
Key facts
Zinc fingers and homeoboxes protein 1 (ZHX1) is a protein from Homo sapiens identified by UniProt accession Q9UKY1, 873 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q9UKY1; gene symbol ZHX1.
- Organism: Homo sapiens.
- Length: 873 amino acids.
- Top disease associations (Open Targets): Parkinson disease, multiple sclerosis and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc fingers and homeoboxes protein 1 |
|---|---|
| UniProt accession | Q9UKY1 |
| Gene | ZHX1 |
| Organism | Homo sapiens |
| Length | 873 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- Parkinson disease · score 0.27
- multiple sclerosis · score 0.27
- neurodegenerative disease · score 0.27
- Alzheimer disease · score 0.27
- lysosomal storage disease · score 0.27
- cholangiocarcinoma · score 0.08
- glioblastoma multiforme · score 0.07
- nonpapillary renal cell carcinoma · score 0.07
- neoplasm · score 0.05
- gonorrhea · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKY1-F1 | alphafold | PREDICTED | 60.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKY1.
Amino-acid sequence (873 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZHX1?
The strongest Open Targets associations for ZHX1 are Parkinson disease, multiple sclerosis, neurodegenerative disease, Alzheimer disease and lysosomal storage disease.
How long is the ZHX1 protein?
The Homo sapiens ZHX1 protein (UniProt Q9UKY1) is 873 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKY1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKY1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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