Protein O-mannosyl-transferase 2 (POMT2)
Homo sapiens — UniProt Q9UKY4
Data last refreshed: (UniProt release unknown)
Key facts
Protein O-mannosyl-transferase 2 (POMT2) is a protein from Homo sapiens identified by UniProt accession Q9UKY4, 750 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.
- UniProt accession: Q9UKY4; gene symbol POMT2.
- Organism: Homo sapiens.
- Length: 750 amino acids.
- Top disease associations (Open Targets): muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A2, muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B2 and autosomal recessive limb-girdle muscular dystrophy type 2N.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein O-mannosyl-transferase 2 |
|---|---|
| UniProt accession | Q9UKY4 |
| Gene | POMT2 |
| Organism | Homo sapiens |
| Length | 750 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (51)
Diseases linked to this target (Open Targets).
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A2 · score 0.82
- muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B2 · score 0.79
- autosomal recessive limb-girdle muscular dystrophy type 2N · score 0.78
- muscular dystrophy-dystroglycanopathy, type A · score 0.67
- limb-girdle muscular dystrophy · score 0.66
- autosomal recessive limb-girdle muscular dystrophy · score 0.57
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A1 · score 0.48
- muscular dystrophy · score 0.47
- qualitative or quantitative defects of alpha-dystroglycan · score 0.46
- genetic disorder · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKY4-F1 | alphafold | PREDICTED | 87.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKY4.
Amino-acid sequence (750 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POMT2?
The strongest Open Targets associations for POMT2 are muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A2, muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B2, autosomal recessive limb-girdle muscular dystrophy type 2N, muscular dystrophy-dystroglycanopathy, type A and limb-girdle muscular dystrophy.
How long is the POMT2 protein?
The Homo sapiens POMT2 protein (UniProt Q9UKY4) is 750 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKY4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKY4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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