CCR4-NOT transcription complex subunit 11 (CNOT11)

About CCR4-NOT transcription complex subunit 11

CCR4-NOT transcription complex subunit 11 (CNOT11) is a protein from Homo sapiens identified by UniProt accession Q9UKZ1, 510 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	CCR4-NOT transcription complex subunit 11
UniProt accession	Q9UKZ1
Gene	CNOT11
Organism	Homo sapiens
Length	510 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
glioblastoma multiforme · score 0.25
breast adenocarcinoma · score 0.25
lung adenocarcinoma · score 0.23
head and neck squamous cell carcinoma · score 0.23
gastric adenocarcinoma · score 0.23
urinary bladder cancer · score 0.23
ovarian cancer · score 0.23
squamous cell lung carcinoma · score 0.23
endometrial cancer · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UKZ1-F1	alphafold	PREDICTED	76.80	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKZ1.

Amino-acid sequence (510 residues)

MPGGGASAAS GRLLTAAEQR GSREAAGSAS RSGFGGSGGG RGGASGPGSG SGGPGGPAGR MSLTPKELSS LLSIISEEAG GGSTFEGLST AFHHYFSKAD HFRLGSVLVM LLQQPDLLPS AAQRLTALYL LWEMYRTEPL AANPFAASFA HLLNPAPPAR GGQEPDRPPL SGFLPPITPP EKFFLSQLML APPRELFKKT PRQIALMDVG NMGQSVDISG LQLALAERQS ELPTQSKASF PSILSDPDPD SSNSGFDSSV ASQITEALVS GPKPPIESHF RPEFIRPPPP LHICEDELAW LNPTEPDHAI QWDKSMCVKN STGVEIKRIM AKAFKSPLSS PQQTQLLGEL EKDPKLVYHI GLTPAKLPDL VENNPLVAIE MLLKLMQSSQ ITEYFSVLVN MDMSLHSMEV VNRLTTAVDL PPEFIHLYIS NCISTCEQIK DKYMQNRLVR LVCVFLQSLI RNKIINVQDL FIEVQAFCIE FSRIREAAGL FRLLKTLDTG ETPSETKMSK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards