Teneurin-1 (TENM1)
Homo sapiens — UniProt Q9UKZ4
Data last refreshed: (UniProt release unknown)
Key facts
Teneurin-1 (TENM1) is a protein from Homo sapiens identified by UniProt accession Q9UKZ4, 2725 residues long. MolForge cross-references it against 0 known binders and 101 disease associations.
- UniProt accession: Q9UKZ4; gene symbol TENM1.
- Organism: Homo sapiens.
- Length: 2725 amino acids.
- Top disease associations (Open Targets): sensorineural hearing loss, Sensorineural hearing impairment and glioblastoma multiforme.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Teneurin-1 |
|---|---|
| UniProt accession | Q9UKZ4 |
| Gene | TENM1 |
| Organism | Homo sapiens |
| Length | 2725 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (101)
Diseases linked to this target (Open Targets).
- sensorineural hearing loss · score 0.12
- Sensorineural hearing impairment · score 0.12
- glioblastoma multiforme · score 0.10
- Blackfan-Diamond anemia · score 0.09
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.08
- hemoglobin E-beta-thalassemia syndrome · score 0.07
- hemoglobin D disease · score 0.07
- delta-beta-thalassemia · score 0.07
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.07
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.07
3D Structure (8)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKZ4-F6 | alphafold | PREDICTED | 91.75 | — |
| AF-Q9UKZ4-F5 | alphafold | PREDICTED | 90.25 | — |
| AF-Q9UKZ4-F8 | alphafold | PREDICTED | 89.21 | — |
| AF-Q9UKZ4-F7 | alphafold | PREDICTED | 88.51 | — |
| AF-Q9UKZ4-F4 | alphafold | PREDICTED | 86.94 | — |
| AF-Q9UKZ4-F3 | alphafold | PREDICTED | 84.34 | — |
| AF-Q9UKZ4-F2 | alphafold | PREDICTED | 78.52 | — |
| AF-Q9UKZ4-F1 | alphafold | PREDICTED | 69.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKZ4.
Amino-acid sequence (2725 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TENM1?
The strongest Open Targets associations for TENM1 are sensorineural hearing loss, Sensorineural hearing impairment, glioblastoma multiforme, Blackfan-Diamond anemia and hereditary persistence of fetal hemoglobin-sickle cell disease syndrome.
How long is the TENM1 protein?
The Homo sapiens TENM1 protein (UniProt Q9UKZ4) is 2725 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKZ4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKZ4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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