Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2)
Homo sapiens — UniProt Q9UL51
Data last refreshed: (UniProt release unknown)
Key facts
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2) is a protein from Homo sapiens identified by UniProt accession Q9UL51, 889 residues long. MolForge cross-references it against 2 known binders and 465 disease associations.
- UniProt accession: Q9UL51; gene symbol HCN2.
- Organism: Homo sapiens.
- Length: 889 amino acids.
- Approved drugs acting on it (DrugCentral): Dronedarone and Ivabradine.
- Top disease associations (Open Targets): neurodegenerative disease, febrile seizures, familial, 2 and Febrile seizure (within the age range of 3 months to 6 years).
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 |
|---|---|
| UniProt accession | Q9UL51 |
| Gene | HCN2 |
| Organism | Homo sapiens |
| Length | 889 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (2)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (465)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- febrile seizures, familial, 2 · score 0.46
- Febrile seizure (within the age range of 3 months to 6 years) · score 0.39
- generalized epilepsy with febrile seizures plus · score 0.37
- Parkinson disease · score 0.33
- Alzheimer disease · score 0.32
- lysosomal storage disease · score 0.32
- multiple sclerosis · score 0.32
- Neurodevelopmental delay · score 0.27
- bone density · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UL51-F1 | alphafold | PREDICTED | 70.13 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UL51.
Amino-acid sequence (889 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target HCN2?
DrugCentral lists 2 approved drugs whose mechanism of action is HCN2: Dronedarone and Ivabradine.
Which diseases are associated with HCN2?
The strongest Open Targets associations for HCN2 are neurodegenerative disease, febrile seizures, familial, 2, Febrile seizure (within the age range of 3 months to 6 years), generalized epilepsy with febrile seizures plus and Parkinson disease.
How long is the HCN2 protein?
The Homo sapiens HCN2 protein (UniProt Q9UL51) is 889 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UL51 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UL51 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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