Aspartyl aminopeptidase (DNPEP)
Homo sapiens — UniProt Q9ULA0
Data last refreshed: (UniProt release unknown)
Key facts
Aspartyl aminopeptidase (DNPEP) is a protein from Homo sapiens identified by UniProt accession Q9ULA0, 485 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.
- UniProt accession: Q9ULA0; gene symbol DNPEP.
- Organism: Homo sapiens.
- Length: 485 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lysosomal storage disease and multiple sclerosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Aspartyl aminopeptidase |
|---|---|
| UniProt accession | Q9ULA0 |
| Gene | DNPEP |
| Organism | Homo sapiens |
| Length | 485 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (38)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.43
- lysosomal storage disease · score 0.36
- multiple sclerosis · score 0.36
- Alzheimer disease · score 0.36
- Parkinson disease · score 0.36
- neuroinflammatory disorder · score 0.14
- acute myeloid leukemia · score 0.09
- myelodysplastic syndrome · score 0.07
- thrombocytopenia 4 · score 0.05
- macrothrombocytopenia, isolated, 2, autosomal dominant · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9ULA0-F1 | alphafold | PREDICTED | 95.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9ULA0.
Amino-acid sequence (485 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DNPEP?
The strongest Open Targets associations for DNPEP are neurodegenerative disease, lysosomal storage disease, multiple sclerosis, Alzheimer disease and Parkinson disease.
How long is the DNPEP protein?
The Homo sapiens DNPEP protein (UniProt Q9ULA0) is 485 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9ULA0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9ULA0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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