Kinase D-interacting substrate of 220 kDa (KIDINS220)

Homo sapiens — UniProt Q9ULH0

Gene: KIDINS220Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Kinase D-interacting substrate of 220 kDa (KIDINS220) is a protein from Homo sapiens identified by UniProt accession Q9ULH0, 1771 residues long. MolForge cross-references it against 0 known binders and 141 disease associations.

UniProt accession: Q9ULH0; gene symbol KIDINS220.
Organism: Homo sapiens.
Length: 1771 amino acids.
Top disease associations (Open Targets): spastic paraplegia, intellectual disability, nystagmus, and obesity, ventriculomegaly and arthrogryposis and neurodegenerative disease.
3D structure: AlphaFold model available.

Target properties

Protein name	Kinase D-interacting substrate of 220 kDa
UniProt accession	Q9ULH0
Gene	KIDINS220
Organism	Homo sapiens
Length	1771 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (141)

Diseases linked to this target (Open Targets).

spastic paraplegia, intellectual disability, nystagmus, and obesity · score 0.76
ventriculomegaly and arthrogryposis · score 0.66
neurodegenerative disease · score 0.44
genetic disorder · score 0.38
neuroinflammatory disorder · score 0.37
thyroid gland adenocarcinoma · score 0.27
cerebral palsy · score 0.27
glioblastoma multiforme · score 0.25
ovarian carcinoma · score 0.15
endometrial carcinoma · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9ULH0-F1	alphafold	PREDICTED	61.66	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9ULH0.

Amino-acid sequence (1771 residues)

MSVLISQSVI NYVEEENIPA LKALLEKCKD VDERNECGQT PLMIAAEQGN LEIVKELIKN GANCNLEDLD NWTALISASK EGHVHIVEEL LKCGVNLEHR DMGGWTALMW ACYKGRTDVV ELLLSHGANP SVTGLYSVYP IIWAAGRGHA DIVHLLLQNG AKVNCSDKYG TTPLVWAARK GHLECVKHLL AMGADVDQEG ANSMTALIVA VKGGYTQSVK EILKRNPNVN LTDKDGNTAL MIASKEGHTE IVQDLLDAGT YVNIPDRSGD TVLIGAVRGG HVEIVRALLQ KYADIDIRGQ DNKTALYWAV EKGNATMVRD ILQCNPDTEI CTKDGETPLI KATKMRNIEV VELLLDKGAK VSAVDKKGDT PLHIAIRGRS RKLAELLLRN PKDGRLLYRP NKAGETPYNI DCSHQKSILT QIFGARHLSP TETDGDMLGY DLYSSALADI LSEPTMQPPI CVGLYAQWGS GKSFLLKKLE DEMKTFAGQQ IEPLFQFSWL IVFLTLLLCG GLGLLFAFTV HPNLGIAVSL SFLALLYIFF IVIYFGGRRE GESWNWAWVL STRLARHIGY LELLLKLMFV NPPELPEQTT KALPVRFLFT DYNRLSSVGG ETSLAEMIAT LSDACEREFG FLATRLFRVF KTEDTQGKKK WKKTCCLPSF VIFLFIIGCI ISGITLLAIF RVDPKHLTVN AVLISIASVV GLAFVLNCRT WWQVLDSLLN SQRKRLHNAA SKLHKLKSEG FMKVLKCEVE LMARMAKTID SFTQNQTRLV VIIDGLDACE QDKVLQMLDT VRVLFSKGPF IAIFASDPHI IIKAINQNLN SVLRDSNING HDYMRNIVHL PVFLNSRGLS NARKFLVTSA TNGDVPCSDT TGIQEDADRR VSQNSLGEMT KLGSKTALNR RDTYRRRQMQ RTITRQMSFD LTKLLVTEDW FSDISPQTMR RLLNIVSVTG RLLRANQISF NWDRLASWIN LTEQWPYRTS WLILYLEETE GIPDQMTLKT IYERISKNIP TTKDVEPLLE IDGDIRNFEV FLSSRTPVLV ARDVKVFLPC TVNLDPKLRE IIADVRAARE QISIGGLAYP PLPLHEGPPR APSGYSQPPS VCSSTSFNGP FAGGVVSPQP HSSYYSGMTG PQHPFYNRPF FAPYLYTPRY YPGGSQHLIS RPSVKTSLPR DQNNGLEVIK EDAAEGLSSP TDSSRGSGPA PGPVVLLNSL NVDAVCEKLK QIEGLDQSML PQYCTTIKKA NINGRVLAQC NIDELKKEMN MNFGDWHLFR STVLEMRNAE SHVVPEDPRF LSESSSGPAP HGEPARRASH NELPHTELSS QTPYTLNFSF EELNTLGLDE GAPRHSNLSW QSQTRRTPSL SSLNSQDSSI EISKLTDKVQ AEYRDAYREY IAQMSQLEGG PGSTTISGRS SPHSTYYMGQ SSSGGSIHSN LEQEKGKDSE PKPDDGRKSF LMKRGDVIDY SSSGVSTNDA SPLDPITEED EKSDQSGSKL LPGKKSSERS SLFQTDLKLK GSGLRYQKLP SDEDESGTEE SDNTPLLKDD KDRKAEGKVE RVPKSPEHSA EPIRTFIKAK EYLSDALLDK KDSSDSGVRS SESSPNHSLH NEVADDSQLE KANLIELEDD SHSGKRGIPH SLSGLQDPII ARMSICSEDK KSPSECSLIA SSPEENWPAC QKAYNLNRTP STVTLNNNSA PANRANQNFD EMEGIRETSQ VILRPSSSPN PTTIQNENLK SMTHKRSQRS SYTRLSKDPP ELHAAASSES TGFGEERESI L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with KIDINS220?

The strongest Open Targets associations for KIDINS220 are spastic paraplegia, intellectual disability, nystagmus, and obesity, ventriculomegaly and arthrogryposis, neurodegenerative disease, genetic disorder and neuroinflammatory disorder.

How long is the KIDINS220 protein?

The Homo sapiens KIDINS220 protein (UniProt Q9ULH0) is 1771 amino acids long.

Browse: Targets: K · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q9ULH0 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q9ULH0 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

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