Leucine-rich repeat and fibronectin type-III domain-containing protein 2 (LRFN2)
Homo sapiens — UniProt Q9ULH4
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat and fibronectin type-III domain-containing protein 2 (LRFN2) is a protein from Homo sapiens identified by UniProt accession Q9ULH4, 789 residues long. MolForge cross-references it against 0 known binders and 238 disease associations.
- UniProt accession: Q9ULH4; gene symbol LRFN2.
- Organism: Homo sapiens.
- Length: 789 amino acids.
- Top disease associations (Open Targets): lean body mass, body mass index and body fat percentage.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat and fibronectin type-III domain-containing protein 2 |
|---|---|
| UniProt accession | Q9ULH4 |
| Gene | LRFN2 |
| Organism | Homo sapiens |
| Length | 789 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (238)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.51
- body mass index · score 0.51
- body fat percentage · score 0.50
- type 2 diabetes mellitus · score 0.49
- fat body mass · score 0.47
- body weight · score 0.45
- squamous cell carcinoma · score 0.40
- risk-taking behaviour · score 0.39
- mathematical ability · score 0.39
- self reported educational attainment · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9ULH4-F1 | alphafold | PREDICTED | 69.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9ULH4.
Amino-acid sequence (789 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRFN2?
The strongest Open Targets associations for LRFN2 are lean body mass, body mass index, body fat percentage, type 2 diabetes mellitus and fat body mass.
How long is the LRFN2 protein?
The Homo sapiens LRFN2 protein (UniProt Q9ULH4) is 789 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9ULH4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9ULH4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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