NACHT and WD repeat domain-containing protein 2 (NWD2)

Homo sapiens — UniProt Q9ULI1

Gene: NWD2Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

NACHT and WD repeat domain-containing protein 2 (NWD2) is a protein from Homo sapiens identified by UniProt accession Q9ULI1, 1742 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

UniProt accession: Q9ULI1; gene symbol NWD2.
Organism: Homo sapiens.
Length: 1742 amino acids.
Top disease associations (Open Targets): alkaline phosphatase measurement, high density lipoprotein cholesterol measurement and sex hormone-binding globulin measurement.
3D structure: AlphaFold model available.

Target properties

Protein name	NACHT and WD repeat domain-containing protein 2
UniProt accession	Q9ULI1
Gene	NWD2
Organism	Homo sapiens
Length	1742 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

alkaline phosphatase measurement · score 0.35
high density lipoprotein cholesterol measurement · score 0.27
sex hormone-binding globulin measurement · score 0.18
protein measurement · score 0.15
episodic memory · score 0.15
daytime rest measurement · score 0.13
central nervous system cancer · score 0.04
body mass index · score 0.04
glioblastoma multiforme · score 0.04
atypical teratoid rhabdoid tumor · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9ULI1-F1	alphafold	PREDICTED	79.39	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9ULI1.

Amino-acid sequence (1742 residues)

MWPAGAGTKL PCPRDSALRR AAFSGNLTAL PSHLVPAGRS VRVFISANPE DTGAERQALR ENVYPKLREF CRENYGLEFQ VIDLYWGVEE DEWDSPELQK TRMKLLENCL KTSAGPCFVG LLGEKYGNIR IPGEVEASEF EMILDAAIEA KLETKLLEEW YCRDENSVPA AYYLRPKSEM LRSNRNAMQP STNAENEKTW QEISDEIKKI FKAAVKLLHE KGKMKHSQAK RYLFSAIEDE FDFALGKQTP AFLKKCVCYI RKIANIERFV KIPEMGKYMD ITGTEPRIIR DPEAQEKLIK LRDEFIPTIV ASSNLRVYTS VTHCDMKLGY SQEIENHYIE GLGKQFYEDM IDIIQATIQQ NFDTETDTLY DEILQHSSLC KTYASFYEYK CESLNIVHNY ILPSKAGHIN PLIIYGGPCT GKTLLLAEVA KKAYGWLHED TGPESDPVVI VRFLGTTDMS SDLRTLLLSV CEQLAVNYRC LVQSYPKKIH DLCDLFINLL NESSLQRPLV IIFDALEQLS ENDDARKLWW LPAHLPRFVR IVLSTLPNKH GILQKLRCLI HEEDNYIELI PRDRKMCSQV LKHQLLRVKR KVTSGQQIYV NNALSKCTLP MFVNLTFREV RHWRSHKDVD ESSLSVTVHE SIEQLFWSLE KKCGQKLVSR ALGYITMAKM GLSEMELEDV LALDNSVMSE LKENTRPSNP LRVPYLYIAR LKEGLSGYLI ERHVKNVTLL VWANRHLQLI AQKLYLQDDN DLREMHTILA DYFLGVWSGG RRKAFCLEDP YLNGCLDLEN RSLLEEEKHF MEQASFDRQA PDQPWVFQCN PLEPDIFFVN HRKMSELLYH LTRCGKTDDL LYGIIMNFSW LYTMIKIGQF DKVLSDIELA YNYSQEKELK FLANTLRSIK NKVTAFPGSL SAELQQRLLP VVSSLPKLRH LLLECDKDGP KYCSIVPLHS SMDVTYSPER LPLSSSHLHV TEILPTCNPS TVLTALENGS ISTWDVETRQ LLRQITTAQS VILGMKLTSD EKYLVVATTN NTLLIYDNVN SCLLSEVEIK GTKHGSSATY INGFTLSANH ALAWLEASKD VTVIDLLYGW PLYQFHCWYE VTCVQCSLDG LYAFCGQYLN TTTIFHLGSG EKLCTVTSEF SGGFVKFLLI LDTAQEMVMV DSEGSLSVWN TEDISSPQLT DDFDCRREDS EVVSIELSED QSAVLICKAL SIELLDTGLW KVAEKFRAKH NERFISAVLS KNGDCIIATM ENTSAVFFWR RDTGQCMASL QEISGSIVKL VKSSHHNMLL SLSTSGVLSI WDIDIITAMS NIDKTGKPIQ SLLLPARGEI IYSLDGSDCV HKWNFSSGFI EAVFKHEGIV EHCVLTSTGD IMVTSDDKSS QYVWHTSSGE NLFRINGQRI SQLLITHNDQ FVVSLCEENA SRVWRLATGH RVCNILTTLQ NAFITSANTF VVGMTKSKVL AVSLWTGSIT KKFCCEDGTT IVNFKLIPDC PDIIVFITSA ETVNIWSLTD EVICRRVQLP NNFLKNLEDF EISPNGKLGI IARGDENINV LDLYSGKLRV VHASGIIWRQ RLSRDGRYLV YICFRNGEEE DENGAIFSLI VMRLADGKNI GACSLYKTPT FLALSQRHLN IIVGFDDGSI GIYTVVDRVD AALKIKIATS NSRQIFNNAT HTSRPKCNSY CFKISVDCLW RESTEVFARD SPITVSDSTE SNEATPSKKH NSCYERVCSA LEARGHSYAP DN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with NWD2?

The strongest Open Targets associations for NWD2 are alkaline phosphatase measurement, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement, protein measurement and episodic memory.

How long is the NWD2 protein?

The Homo sapiens NWD2 protein (UniProt Q9ULI1) is 1742 amino acids long.

Browse: Targets: N · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q9ULI1 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q9ULI1 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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