Mediator of RNA polymerase II transcription subunit 23 (MED23)
Homo sapiens — UniProt Q9ULK4
Data last refreshed: (UniProt release unknown)
Key facts
Mediator of RNA polymerase II transcription subunit 23 (MED23) is a protein from Homo sapiens identified by UniProt accession Q9ULK4, 1368 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.
- UniProt accession: Q9ULK4; gene symbol MED23.
- Organism: Homo sapiens.
- Length: 1368 amino acids.
- Top disease associations (Open Targets): autosomal recessive non-syndromic intellectual disability, hyperargininemia and Argininemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mediator of RNA polymerase II transcription subunit 23 |
|---|---|
| UniProt accession | Q9ULK4 |
| Gene | MED23 |
| Organism | Homo sapiens |
| Length | 1368 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (78)
Diseases linked to this target (Open Targets).
- autosomal recessive non-syndromic intellectual disability · score 0.63
- hyperargininemia · score 0.57
- Argininemia · score 0.57
- genetic disorder · score 0.47
- neurodegenerative disease · score 0.46
- Intellectual disability · score 0.45
- breast adenocarcinoma · score 0.34
- vitamin D measurement · score 0.34
- creatinine measurement · score 0.33
- body mass index · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9ULK4-F1 | alphafold | PREDICTED | 86.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9ULK4.
Amino-acid sequence (1368 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MED23?
The strongest Open Targets associations for MED23 are autosomal recessive non-syndromic intellectual disability, hyperargininemia, Argininemia, genetic disorder and neurodegenerative disease.
How long is the MED23 protein?
The Homo sapiens MED23 protein (UniProt Q9ULK4) is 1368 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9ULK4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9ULK4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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