Vang-like protein 2 (VANGL2)
Homo sapiens — UniProt Q9ULK5
Data last refreshed: (UniProt release unknown)
Key facts
Vang-like protein 2 (VANGL2) is a protein from Homo sapiens identified by UniProt accession Q9ULK5, 521 residues long. MolForge cross-references it against 0 known binders and 379 disease associations.
- UniProt accession: Q9ULK5; gene symbol VANGL2.
- Organism: Homo sapiens.
- Length: 521 amino acids.
- Top disease associations (Open Targets): spina bifida, body height and cortical surface area measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Vang-like protein 2 |
|---|---|
| UniProt accession | Q9ULK5 |
| Gene | VANGL2 |
| Organism | Homo sapiens |
| Length | 521 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (379)
Diseases linked to this target (Open Targets).
- spina bifida · score 0.52
- body height · score 0.32
- cortical surface area measurement · score 0.31
- brain measurement · score 0.29
- BMI-adjusted waist-hip ratio · score 0.28
- neuroimaging measurement · score 0.28
- cortical thickness · score 0.28
- multiple sclerosis · score 0.26
- BMI-adjusted waist circumference · score 0.21
- hypothyroidism · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9ULK5-F1 | alphafold | PREDICTED | 73.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9ULK5.
Amino-acid sequence (521 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VANGL2?
The strongest Open Targets associations for VANGL2 are spina bifida, body height, cortical surface area measurement, brain measurement and BMI-adjusted waist-hip ratio.
How long is the VANGL2 protein?
The Homo sapiens VANGL2 protein (UniProt Q9ULK5) is 521 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9ULK5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9ULK5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.