Pleckstrin homology domain-containing family H member 1 (PLEKHH1)
Homo sapiens — UniProt Q9ULM0
Data last refreshed: (UniProt release unknown)
Key facts
Pleckstrin homology domain-containing family H member 1 (PLEKHH1) is a protein from Homo sapiens identified by UniProt accession Q9ULM0, 1364 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.
- UniProt accession: Q9ULM0; gene symbol PLEKHH1.
- Organism: Homo sapiens.
- Length: 1364 amino acids.
- Top disease associations (Open Targets): urate measurement, cystatin C measurement and uric acid measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pleckstrin homology domain-containing family H member 1 |
|---|---|
| UniProt accession | Q9ULM0 |
| Gene | PLEKHH1 |
| Organism | Homo sapiens |
| Length | 1364 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (35)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.37
- cystatin C measurement · score 0.29
- uric acid measurement · score 0.29
- diastolic blood pressure · score 0.25
- serum metabolite measurement · score 0.17
- glycerophospholipid measurement · score 0.15
- blood metabolite measurement · score 0.15
- phosphatidylcholine measurement · score 0.14
- phosphatidylinositol measurement · score 0.13
- lysophosphatidylcholine measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9ULM0-F1 | alphafold | PREDICTED | 69.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9ULM0.
Amino-acid sequence (1364 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLEKHH1?
The strongest Open Targets associations for PLEKHH1 are urate measurement, cystatin C measurement, uric acid measurement, diastolic blood pressure and serum metabolite measurement.
How long is the PLEKHH1 protein?
The Homo sapiens PLEKHH1 protein (UniProt Q9ULM0) is 1364 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9ULM0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9ULM0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.