CCR4-NOT transcription complex subunit 6 (CNOT6)
Homo sapiens — UniProt Q9ULM6
Data last refreshed: (UniProt release unknown)
Key facts
CCR4-NOT transcription complex subunit 6 (CNOT6) is a protein from Homo sapiens identified by UniProt accession Q9ULM6, 557 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: Q9ULM6; gene symbol CNOT6.
- Organism: Homo sapiens.
- Length: 557 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lysosomal storage disease and acute myeloid leukemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | CCR4-NOT transcription complex subunit 6 |
|---|---|
| UniProt accession | Q9ULM6 |
| Gene | CNOT6 |
| Organism | Homo sapiens |
| Length | 557 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- lysosomal storage disease · score 0.35
- acute myeloid leukemia · score 0.27
- breast adenocarcinoma · score 0.26
- endometrial cancer · score 0.26
- head and neck squamous cell carcinoma · score 0.25
- mean reticulocyte volume · score 0.24
- mean corpuscular volume · score 0.23
- gastric adenocarcinoma · score 0.23
- squamous cell lung carcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9ULM6-F1 | alphafold | PREDICTED | 89.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9ULM6.
Amino-acid sequence (557 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CNOT6?
The strongest Open Targets associations for CNOT6 are neurodegenerative disease, lysosomal storage disease, acute myeloid leukemia, breast adenocarcinoma and endometrial cancer.
How long is the CNOT6 protein?
The Homo sapiens CNOT6 protein (UniProt Q9ULM6) is 557 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9ULM6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9ULM6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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