Two pore channel protein 1 (TPCN1)
Homo sapiens — UniProt Q9ULQ1
Data last refreshed: (UniProt release unknown)
Key facts
Two pore channel protein 1 (TPCN1) is a protein from Homo sapiens identified by UniProt accession Q9ULQ1, 816 residues long. MolForge cross-references it against 1 known binders and 101 disease associations.
- UniProt accession: Q9ULQ1; gene symbol TPCN1.
- Organism: Homo sapiens.
- Length: 816 amino acids.
- Approved drugs acting on it (DrugCentral): Verapamil.
- Top disease associations (Open Targets): glioblastoma multiforme, body mass index and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Two pore channel protein 1 |
|---|---|
| UniProt accession | Q9ULQ1 |
| Gene | TPCN1 |
| Organism | Homo sapiens |
| Length | 816 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (101)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.18
- body mass index · score 0.17
- breast adenocarcinoma · score 0.16
- response to fenofibrate · score 0.12
- head and neck squamous cell carcinoma · score 0.12
- blood protein measurement · score 0.08
- nephrotic syndrome · score 0.06
- familial idiopathic steroid-resistant nephrotic syndrome · score 0.05
- focal segmental glomerulosclerosis · score 0.05
- hemoglobin D disease · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9ULQ1-F1 | alphafold | PREDICTED | 84.48 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9ULQ1.
Amino-acid sequence (816 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target TPCN1?
DrugCentral lists 1 approved drug whose mechanism of action is TPCN1: Verapamil.
Which diseases are associated with TPCN1?
The strongest Open Targets associations for TPCN1 are glioblastoma multiforme, body mass index, breast adenocarcinoma, response to fenofibrate and head and neck squamous cell carcinoma.
How long is the TPCN1 protein?
The Homo sapiens TPCN1 protein (UniProt Q9ULQ1) is 816 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9ULQ1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9ULQ1 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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