Delayed-rectifier potassium channel regulatory subunit KCNS2 (KCNS2)
Homo sapiens — UniProt Q9ULS6
Data last refreshed: (UniProt release unknown)
Key facts
Delayed-rectifier potassium channel regulatory subunit KCNS2 (KCNS2) is a protein from Homo sapiens identified by UniProt accession Q9ULS6, 477 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q9ULS6; gene symbol KCNS2.
- Organism: Homo sapiens.
- Length: 477 amino acids.
- Top disease associations (Open Targets): multiple sclerosis, Myasthenia gravis and Muscle weakness.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Delayed-rectifier potassium channel regulatory subunit KCNS2 |
|---|---|
| UniProt accession | Q9ULS6 |
| Gene | KCNS2 |
| Organism | Homo sapiens |
| Length | 477 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- multiple sclerosis · score 0.59
- Myasthenia gravis · score 0.57
- Muscle weakness · score 0.46
- small cell carcinoma · score 0.46
- secondary progressive multiple sclerosis · score 0.43
- anterior ischemic optic neuropathy · score 0.37
- primary progressive multiple sclerosis · score 0.37
- transverse myelitis · score 0.37
- atrial fibrillation · score 0.35
- atrial flutter · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9ULS6-F1 | alphafold | PREDICTED | 80.91 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9ULS6.
Amino-acid sequence (477 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KCNS2?
The strongest Open Targets associations for KCNS2 are multiple sclerosis, Myasthenia gravis, Muscle weakness, small cell carcinoma and secondary progressive multiple sclerosis.
How long is the KCNS2 protein?
The Homo sapiens KCNS2 protein (UniProt Q9ULS6) is 477 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9ULS6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9ULS6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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