Frizzled-4 (FZD4)
Homo sapiens — UniProt Q9ULV1
Data last refreshed: (UniProt release unknown)
Key facts
Frizzled-4 (FZD4) is a protein from Homo sapiens identified by UniProt accession Q9ULV1, 537 residues long. MolForge cross-references it against 0 known binders and 186 disease associations.
- UniProt accession: Q9ULV1; gene symbol FZD4.
- Organism: Homo sapiens.
- Length: 537 amino acids.
- Top disease associations (Open Targets): Familial exudative vitreoretinopathy, Coats disease and Retinal dystrophy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Frizzled-4 |
|---|---|
| UniProt accession | Q9ULV1 |
| Gene | FZD4 |
| Organism | Homo sapiens |
| Length | 537 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (186)
Diseases linked to this target (Open Targets).
- Familial exudative vitreoretinopathy · score 0.81
- Coats disease · score 0.42
- Retinal dystrophy · score 0.38
- exudative vitreoretinopathy · score 0.37
- persistent hyperplastic primary vitreous · score 0.37
- retinopathy of prematurity · score 0.35
- Norrie disease · score 0.34
- endometrial cancer · score 0.25
- medulloblastoma · score 0.21
- lung adenocarcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9ULV1-F1 | alphafold | PREDICTED | 84.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9ULV1.
Amino-acid sequence (537 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FZD4?
The strongest Open Targets associations for FZD4 are Familial exudative vitreoretinopathy, Coats disease, Retinal dystrophy, exudative vitreoretinopathy and persistent hyperplastic primary vitreous.
How long is the FZD4 protein?
The Homo sapiens FZD4 protein (UniProt Q9ULV1) is 537 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9ULV1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9ULV1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.