Heat shock factor protein 4 (HSF4)
Homo sapiens — UniProt Q9ULV5
Data last refreshed: (UniProt release unknown)
Key facts
Heat shock factor protein 4 (HSF4) is a protein from Homo sapiens identified by UniProt accession Q9ULV5, 492 residues long. MolForge cross-references it against 0 known binders and 308 disease associations.
- UniProt accession: Q9ULV5; gene symbol HSF4.
- Organism: Homo sapiens.
- Length: 492 amino acids.
- Top disease associations (Open Targets): cataract 5 multiple types, early-onset zonular cataract and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Heat shock factor protein 4 |
|---|---|
| UniProt accession | Q9ULV5 |
| Gene | HSF4 |
| Organism | Homo sapiens |
| Length | 492 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (308)
Diseases linked to this target (Open Targets).
- cataract 5 multiple types · score 0.79
- early-onset zonular cataract · score 0.55
- neurodegenerative disease · score 0.46
- total early-onset cataract · score 0.37
- early-onset non-syndromic cataract · score 0.29
- Developmental cataract · score 0.27
- genetic disorder · score 0.19
- cataract · score 0.17
- isolated ectopia lentis · score 0.11
- hereditary hyperferritinemia with congenital cataracts · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9ULV5-F1 | alphafold | PREDICTED | 59.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9ULV5.
Amino-acid sequence (492 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HSF4?
The strongest Open Targets associations for HSF4 are cataract 5 multiple types, early-onset zonular cataract, neurodegenerative disease, total early-onset cataract and early-onset non-syndromic cataract.
How long is the HSF4 protein?
The Homo sapiens HSF4 protein (UniProt Q9ULV5) is 492 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9ULV5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9ULV5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.