E3 ubiquitin-protein ligase CBL-C (CBLC)
Homo sapiens — UniProt Q9ULV8
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase CBL-C (CBLC) is a protein from Homo sapiens identified by UniProt accession Q9ULV8, 474 residues long. MolForge cross-references it against 0 known binders and 199 disease associations.
- UniProt accession: Q9ULV8; gene symbol CBLC.
- Organism: Homo sapiens.
- Length: 474 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, colorectal adenocarcinoma and Placental Choriocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase CBL-C |
|---|---|
| UniProt accession | Q9ULV8 |
| Gene | CBLC |
| Organism | Homo sapiens |
| Length | 474 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (199)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.39
- colorectal adenocarcinoma · score 0.37
- Placental Choriocarcinoma · score 0.37
- bile duct carcinoma · score 0.37
- gliomatosis cerebri · score 0.37
- hemangioblastoma · score 0.37
- cutaneous melanoma · score 0.37
- breast ductal adenocarcinoma · score 0.37
- low density lipoprotein cholesterol measurement · score 0.31
- non-small cell lung carcinoma · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9ULV8-F1 | alphafold | PREDICTED | 80.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9ULV8.
Amino-acid sequence (474 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CBLC?
The strongest Open Targets associations for CBLC are neurodegenerative disease, colorectal adenocarcinoma, Placental Choriocarcinoma, bile duct carcinoma and gliomatosis cerebri.
How long is the CBLC protein?
The Homo sapiens CBLC protein (UniProt Q9ULV8) is 474 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9ULV8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9ULV8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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