Activator of basal transcription 1 (ABT1)
Homo sapiens — UniProt Q9ULW3
Data last refreshed: (UniProt release unknown)
Key facts
Activator of basal transcription 1 (ABT1) is a protein from Homo sapiens identified by UniProt accession Q9ULW3, 272 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.
- UniProt accession: Q9ULW3; gene symbol ABT1.
- Organism: Homo sapiens.
- Length: 272 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, self reported educational attainment and urate measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Activator of basal transcription 1 |
|---|---|
| UniProt accession | Q9ULW3 |
| Gene | ABT1 |
| Organism | Homo sapiens |
| Length | 272 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (78)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- self reported educational attainment · score 0.15
- urate measurement · score 0.12
- diastolic blood pressure · score 0.10
- sex hormone-binding globulin measurement · score 0.08
- diet measurement · score 0.07
- systemic lupus erythematosus · score 0.07
- hip circumference · score 0.06
- mathematical ability · score 0.05
- reticulocyte count · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9ULW3-F1 | alphafold | PREDICTED | 77.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9ULW3.
Amino-acid sequence (272 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ABT1?
The strongest Open Targets associations for ABT1 are neurodegenerative disease, self reported educational attainment, urate measurement, diastolic blood pressure and sex hormone-binding globulin measurement.
How long is the ABT1 protein?
The Homo sapiens ABT1 protein (UniProt Q9ULW3) is 272 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9ULW3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9ULW3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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