Protein-arginine deiminase type-3 (PADI3)
Homo sapiens — UniProt Q9ULW8
Data last refreshed: (UniProt release unknown)
Key facts
Protein-arginine deiminase type-3 (PADI3) is a protein from Homo sapiens identified by UniProt accession Q9ULW8, 664 residues long. MolForge cross-references it against 0 known binders and 107 disease associations.
- UniProt accession: Q9ULW8; gene symbol PADI3.
- Organism: Homo sapiens.
- Length: 664 amino acids.
- Top disease associations (Open Targets): uncombable hair syndrome, central centrifugal cicatricial alopecia and hair color.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein-arginine deiminase type-3 |
|---|---|
| UniProt accession | Q9ULW8 |
| Gene | PADI3 |
| Organism | Homo sapiens |
| Length | 664 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (107)
Diseases linked to this target (Open Targets).
- uncombable hair syndrome · score 0.58
- central centrifugal cicatricial alopecia · score 0.51
- hair color · score 0.41
- hair colour measurement · score 0.35
- vitamin D measurement · score 0.27
- breast adenocarcinoma · score 0.22
- genetic disorder · score 0.19
- hair shape measurement · score 0.16
- vitamin D deficiency · score 0.10
- ringed hair disease · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9ULW8-F1 | alphafold | PREDICTED | 93.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9ULW8.
Amino-acid sequence (664 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PADI3?
The strongest Open Targets associations for PADI3 are uncombable hair syndrome, central centrifugal cicatricial alopecia, hair color, hair colour measurement and vitamin D measurement.
How long is the PADI3 protein?
The Homo sapiens PADI3 protein (UniProt Q9ULW8) is 664 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9ULW8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9ULW8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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