A-kinase anchor protein 8-like (AKAP8L)
Homo sapiens — UniProt Q9ULX6
Data last refreshed: (UniProt release unknown)
Key facts
A-kinase anchor protein 8-like (AKAP8L) is a protein from Homo sapiens identified by UniProt accession Q9ULX6, 646 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.
- UniProt accession: Q9ULX6; gene symbol AKAP8L.
- Organism: Homo sapiens.
- Length: 646 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Alzheimer disease and lysosomal storage disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | A-kinase anchor protein 8-like |
|---|---|
| UniProt accession | Q9ULX6 |
| Gene | AKAP8L |
| Organism | Homo sapiens |
| Length | 646 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (59)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- Alzheimer disease · score 0.33
- lysosomal storage disease · score 0.33
- multiple sclerosis · score 0.33
- Parkinson disease · score 0.33
- erythrocyte count · score 0.28
- mean corpuscular volume · score 0.26
- mean corpuscular hemoglobin concentration · score 0.24
- neuroinflammatory disorder · score 0.20
- mean corpuscular hemoglobin · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9ULX6-F1 | alphafold | PREDICTED | 54.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9ULX6.
Amino-acid sequence (646 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AKAP8L?
The strongest Open Targets associations for AKAP8L are neurodegenerative disease, Alzheimer disease, lysosomal storage disease, multiple sclerosis and Parkinson disease.
How long is the AKAP8L protein?
The Homo sapiens AKAP8L protein (UniProt Q9ULX6) is 646 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9ULX6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9ULX6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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