Carbonic anhydrase 14 (CA14)
Homo sapiens — UniProt Q9ULX7
Data last refreshed: (UniProt release unknown)
Key facts
Carbonic anhydrase 14 (CA14) is a protein from Homo sapiens identified by UniProt accession Q9ULX7, 337 residues long. MolForge cross-references it against 42 known binders and 74 disease associations.
- UniProt accession: Q9ULX7; gene symbol CA14.
- Organism: Homo sapiens.
- Length: 337 amino acids.
- Approved drugs acting on it (DrugCentral): Ethoxzolamide.
- Top disease associations (Open Targets): epilepsy, circadian rhythm and age-related macular degeneration.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Carbonic anhydrase 14 |
|---|---|
| UniProt accession | Q9ULX7 |
| Gene | CA14 |
| Organism | Homo sapiens |
| Length | 337 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (74)
Diseases linked to this target (Open Targets).
- epilepsy · score 0.44
- circadian rhythm · score 0.20
- age-related macular degeneration · score 0.07
- obstructive sleep apnea · score 0.07
- retinitis pigmentosa · score 0.07
- X-linked retinal dysplasia · score 0.07
- Familial exudative vitreoretinopathy · score 0.07
- severe early-childhood-onset retinal dystrophy · score 0.05
- Sorsby's fundus dystrophy · score 0.05
- neutrophil count · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9ULX7-F1 | alphafold | PREDICTED | 90.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9ULX7.
Amino-acid sequence (337 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target CA14?
DrugCentral lists 1 approved drug whose mechanism of action is CA14: Ethoxzolamide.
Which diseases are associated with CA14?
The strongest Open Targets associations for CA14 are epilepsy, circadian rhythm, age-related macular degeneration, obstructive sleep apnea and retinitis pigmentosa.
How long is the CA14 protein?
The Homo sapiens CA14 protein (UniProt Q9ULX7) is 337 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9ULX7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9ULX7 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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