Apoptosis-associated speck-like protein containing a CARD (PYCARD)
Homo sapiens — UniProt Q9ULZ3
Data last refreshed: (UniProt release unknown)
Key facts
Apoptosis-associated speck-like protein containing a CARD (PYCARD) is a protein from Homo sapiens identified by UniProt accession Q9ULZ3, 195 residues long. MolForge cross-references it against 0 known binders and 256 disease associations.
- UniProt accession: Q9ULZ3; gene symbol PYCARD.
- Organism: Homo sapiens.
- Length: 195 amino acids.
- Top disease associations (Open Targets): severe acute respiratory syndrome, head and neck squamous cell carcinoma and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Apoptosis-associated speck-like protein containing a CARD |
|---|---|
| UniProt accession | Q9ULZ3 |
| Gene | PYCARD |
| Organism | Homo sapiens |
| Length | 195 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (256)
Diseases linked to this target (Open Targets).
- severe acute respiratory syndrome · score 0.37
- head and neck squamous cell carcinoma · score 0.14
- neoplasm · score 0.07
- hyper-IgE recurrent infection syndrome 5, autosomal recessive · score 0.06
- glioblastoma multiforme · score 0.06
- cancer · score 0.06
- gamma chain deficiency · score 0.05
- immunodeficiency 89 and autoimmunity · score 0.05
- Rheumatoid arthritis · score 0.05
- immunodeficiency 18 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9ULZ3-F1 | alphafold | PREDICTED | 72.45 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9ULZ3.
Amino-acid sequence (195 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PYCARD?
The strongest Open Targets associations for PYCARD are severe acute respiratory syndrome, head and neck squamous cell carcinoma, neoplasm, hyper-IgE recurrent infection syndrome 5, autosomal recessive and glioblastoma multiforme.
How long is the PYCARD protein?
The Homo sapiens PYCARD protein (UniProt Q9ULZ3) is 195 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9ULZ3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9ULZ3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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