Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A (MGAT4A)
Homo sapiens — UniProt Q9UM21
Data last refreshed: (UniProt release unknown)
Key facts
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A (MGAT4A) is a protein from Homo sapiens identified by UniProt accession Q9UM21, 535 residues long. MolForge cross-references it against 0 known binders and 126 disease associations.
- UniProt accession: Q9UM21; gene symbol MGAT4A.
- Organism: Homo sapiens.
- Length: 535 amino acids.
- Top disease associations (Open Targets): COVID-19, metastatic colorectal cancer and response to cetuximab.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A |
|---|---|
| UniProt accession | Q9UM21 |
| Gene | MGAT4A |
| Organism | Homo sapiens |
| Length | 535 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (126)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.37
- metastatic colorectal cancer · score 0.28
- response to cetuximab · score 0.28
- response to CAPOX-B · score 0.28
- progression free survival · score 0.28
- eosinophil count · score 0.07
- MODY · score 0.06
- hepatitis C virus infection · score 0.06
- glycogen storage disease VI · score 0.06
- hypoinsulinemic hypoglycemia and body hemihypertrophy · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UM21-F1 | alphafold | PREDICTED | 85.22 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UM21.
Amino-acid sequence (535 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MGAT4A?
The strongest Open Targets associations for MGAT4A are COVID-19, metastatic colorectal cancer, response to cetuximab, response to CAPOX-B and progression free survival.
How long is the MGAT4A protein?
The Homo sapiens MGAT4A protein (UniProt Q9UM21) is 535 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UM21 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UM21 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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