Collagen alpha-1(XVII) chain (COL17A1)

Homo sapiens — UniProt Q9UMD9

Gene: COL17A1Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Collagen alpha-1(XVII) chain (COL17A1) is a protein from Homo sapiens identified by UniProt accession Q9UMD9, 1497 residues long. MolForge cross-references it against 0 known binders and 310 disease associations.

UniProt accession: Q9UMD9; gene symbol COL17A1.
Organism: Homo sapiens.
Length: 1497 amino acids.
Top disease associations (Open Targets): epidermolysis bullosa, junctional 4, intermediate, epithelial recurrent erosion dystrophy and junctional epidermolysis bullosa, non-Herlitz type.
3D structure: AlphaFold model available.

Target properties

Protein name	Collagen alpha-1(XVII) chain
UniProt accession	Q9UMD9
Gene	COL17A1
Organism	Homo sapiens
Length	1497 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (310)

Diseases linked to this target (Open Targets).

epidermolysis bullosa, junctional 4, intermediate · score 0.75
epithelial recurrent erosion dystrophy · score 0.71
junctional epidermolysis bullosa, non-Herlitz type · score 0.64
Hypoplastic amelogenesis imperfecta · score 0.62
amelogenesis imperfecta · score 0.54
junctional epidermolysis bullosa · score 0.54
Generalized junctional epidermolysis bullosa, non-Herlitz type · score 0.47
genetic disorder · score 0.42
Abnormality of the skin · score 0.41
localized junctional epidermolysis bullosa, non-Herlitz type · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UMD9-F1	alphafold	PREDICTED	46.94	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UMD9.

Amino-acid sequence (1497 residues)

MDVTKKNKRD GTEVTERIVT ETVTTRLTSL PPKGGTSNGY AKTASLGGGS RLEKQSLTHG SSGYINSTGS TRGHASTSSY RRAHSPASTL PNSPGSTFER KTHVTRHAYE GSSSGNSSPE YPRKEFASSS TRGRSQTRES EIRVRLQSAS PSTRWTELDD VKRLLKGSRS ASVSPTRNSS NTLPIPKKGT VETKIVTASS QSVSGTYDAT ILDANLPSHV WSSTLPAGSS MGTYHNNMTT QSSSLLNTNA YSAGSVFGVP NNMASCSPTL HPGLSTSSSV FGMQNNLAPS LTTLSHGTTT TSTAYGVKKN MPQSPAAVNT GVSTSAACTT SVQSDDLLHK DCKFLILEKD NTPAKKEMEL LIMTKDSGKV FTASPASIAA TSFSEDTLKK EKQAAYNADS GLKAEANGDL KTVSTKGKTT TADIHSYGSS GGGGSGGGGG VGGAGGGPWG PAPAWCPCGS CCSWWKWLLG LLLTWLLLLG LLFGLIALAE EVRKLKARVD ELERIRRSIL PYGDSMDRIE KDRLQGMAPA AGADLDKIGL HSDSQEELWM FVRKKLMMEQ ENGNLRGSPG PKGDMGSPGP KGDRGFPGTP GIPGPLGHPG PQGPKGQKGS VGDPGMEGPM GQRGREGPMG PRGEAGPPGS GEKGERGAAG EPGPHGPPGV PGSVGPKGSS GSPGPQGPPG PVGLQGLRGE VGLPGVKGDK GPMGPPGPKG DQGEKGPRGL TGEPGMRGLP GAVGEPGAKG AMGPAGPDGH QGPRGEQGLT GMPGIRGPPG PSGDPGKPGL TGPQGPQGLP GTPGRPGIKG EPGAPGKIVT SEGSSMLTVP GPPGPPGAMG PPGPPGAPGP AGPAGLPGHQ EVLNLQGPPG PPGPRGPPGP SIPGPPGPRG PPGEGLPGPP GPPGSFLSNS ETFLSGPPGP PGPPGPKGDQ GPPGPRGHQG EQGLPGFSTS GSSSFGLNLQ GPPGPPGPQG PKGDKGDPGV PGALGIPSGP SEGGSSSTMY VSGPPGPPGP PGPPGSISSS GQEIQQYISE YMQSDSIRSY LSGVQGPPGP PGPPGPVTTI TGETFDYSEL ASHVVSYLRT SGYGVSLFSS SISSEDILAV LQRDDVRQYL RQYLMGPRGP PGPPGASGDG SLLSLDYAEL SSRILSYMSS SGISIGLPGP PGPPGLPGTS YEELLSLLRG SEFRGIVGPP GPPGPPGIPG NVWSSISVED LSSYLHTAGL SFIPGPPGPP GPPGPRGPPG VSGALATYAA ENSDSFRSEL ISYLTSPDVR SFIVGPPGPP GPQGPPGDSR LLSTDASHSR GSSSSSHSSS VRRGSSYSSS MSTGGGGAGS LGAGGAFGEA AGDRGPYGTD IGPGGGYGAA AEGGMYAGNG GLLGADFAGD LDYNELAVRV SESMQRQGLL QGMAYTVQGP PGQPGPQGPP GISKVFSAYS NVTADLMDFF QTYGAIQGPP GQKGEMGTPG PKGDRGPAGP PGHPGPPGPR GHKGEKGDKG DQVYAGRRRR RSIAVKP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with COL17A1?

The strongest Open Targets associations for COL17A1 are epidermolysis bullosa, junctional 4, intermediate, epithelial recurrent erosion dystrophy, junctional epidermolysis bullosa, non-Herlitz type, Hypoplastic amelogenesis imperfecta and amelogenesis imperfecta.

How long is the COL17A1 protein?

The Homo sapiens COL17A1 protein (UniProt Q9UMD9) is 1497 amino acids long.

Browse: Targets: C · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q9UMD9 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q9UMD9 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.