Homeobox protein BarH-like 2 (BARX2)
Homo sapiens — UniProt Q9UMQ3
Data last refreshed: (UniProt release unknown)
Key facts
Homeobox protein BarH-like 2 (BARX2) is a protein from Homo sapiens identified by UniProt accession Q9UMQ3, 279 residues long. MolForge cross-references it against 0 known binders and 174 disease associations.
- UniProt accession: Q9UMQ3; gene symbol BARX2.
- Organism: Homo sapiens.
- Length: 279 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, protein measurement and breast carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Homeobox protein BarH-like 2 |
|---|---|
| UniProt accession | Q9UMQ3 |
| Gene | BARX2 |
| Organism | Homo sapiens |
| Length | 279 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (174)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- protein measurement · score 0.33
- breast carcinoma · score 0.30
- drug use measurement · score 0.15
- neoplasm · score 0.10
- non-small cell lung carcinoma · score 0.09
- gonorrhea · score 0.08
- lung adenocarcinoma · score 0.08
- oral squamous cell carcinoma · score 0.08
- metabolite measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UMQ3-F1 | alphafold | PREDICTED | 64.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UMQ3.
Amino-acid sequence (279 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BARX2?
The strongest Open Targets associations for BARX2 are neurodegenerative disease, protein measurement, breast carcinoma, drug use measurement and neoplasm.
How long is the BARX2 protein?
The Homo sapiens BARX2 protein (UniProt Q9UMQ3) is 279 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UMQ3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UMQ3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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