Lysosomal thioesterase PPT2 (PPT2)
Homo sapiens — UniProt Q9UMR5
Data last refreshed: (UniProt release unknown)
Key facts
Lysosomal thioesterase PPT2 (PPT2) is a protein from Homo sapiens identified by UniProt accession Q9UMR5, 302 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q9UMR5; gene symbol PPT2.
- Organism: Homo sapiens.
- Length: 302 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, birth weight and total blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Lysosomal thioesterase PPT2 |
|---|---|
| UniProt accession | Q9UMR5 |
| Gene | PPT2 |
| Organism | Homo sapiens |
| Length | 302 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- birth weight · score 0.12
- total blood protein measurement · score 0.08
- nonpapillary renal cell carcinoma · score 0.07
- type 2 diabetes mellitus · score 0.06
- angina pectoris · score 0.05
- risk-taking behaviour · score 0.04
- waist circumference · score 0.04
- acute infantile liver failure-cerebellar ataxia-peripheral sensory motor neuropathy syndrome · score 0.04
- pulse pressure measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UMR5-F1 | alphafold | PREDICTED | 91.95 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UMR5.
Amino-acid sequence (302 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PPT2?
The strongest Open Targets associations for PPT2 are neurodegenerative disease, birth weight, total blood protein measurement, nonpapillary renal cell carcinoma and type 2 diabetes mellitus.
How long is the PPT2 protein?
The Homo sapiens PPT2 protein (UniProt Q9UMR5) is 302 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UMR5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UMR5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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