C-type lectin domain family 4 member A (CLEC4A)
Homo sapiens — UniProt Q9UMR7
Data last refreshed: (UniProt release unknown)
Key facts
C-type lectin domain family 4 member A (CLEC4A) is a protein from Homo sapiens identified by UniProt accession Q9UMR7, 237 residues long. MolForge cross-references it against 0 known binders and 200 disease associations.
- UniProt accession: Q9UMR7; gene symbol CLEC4A.
- Organism: Homo sapiens.
- Length: 237 amino acids.
- Top disease associations (Open Targets): velopharyngeal dysfunction, squamous cell lung carcinoma and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | C-type lectin domain family 4 member A |
|---|---|
| UniProt accession | Q9UMR7 |
| Gene | CLEC4A |
| Organism | Homo sapiens |
| Length | 237 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (200)
Diseases linked to this target (Open Targets).
- velopharyngeal dysfunction · score 0.26
- squamous cell lung carcinoma · score 0.17
- breast adenocarcinoma · score 0.16
- endometrial cancer · score 0.15
- Rheumatoid arthritis · score 0.08
- neoplasm · score 0.07
- immunodeficiency 72 with autoinflammation · score 0.05
- hyper-IgM syndrome type 5 · score 0.05
- autoimmune lymphoproliferative syndrome type 2B · score 0.05
- Testicular regression syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UMR7-F1 | alphafold | PREDICTED | 84.07 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UMR7.
Amino-acid sequence (237 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CLEC4A?
The strongest Open Targets associations for CLEC4A are velopharyngeal dysfunction, squamous cell lung carcinoma, breast adenocarcinoma, endometrial cancer and Rheumatoid arthritis.
How long is the CLEC4A protein?
The Homo sapiens CLEC4A protein (UniProt Q9UMR7) is 237 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UMR7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UMR7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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