Ubl carboxyl-terminal hydrolase 18 (USP18)
Homo sapiens — UniProt Q9UMW8
Data last refreshed: (UniProt release unknown)
Key facts
Ubl carboxyl-terminal hydrolase 18 (USP18) is a protein from Homo sapiens identified by UniProt accession Q9UMW8, 372 residues long. MolForge cross-references it against 0 known binders and 368 disease associations.
- UniProt accession: Q9UMW8; gene symbol USP18.
- Organism: Homo sapiens.
- Length: 372 amino acids.
- Top disease associations (Open Targets): Congenital intrauterine infection-like syndrome, pseudo-TORCH syndrome and systemic lupus erythematosus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubl carboxyl-terminal hydrolase 18 |
|---|---|
| UniProt accession | Q9UMW8 |
| Gene | USP18 |
| Organism | Homo sapiens |
| Length | 372 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (368)
Diseases linked to this target (Open Targets).
- Congenital intrauterine infection-like syndrome · score 0.70
- pseudo-TORCH syndrome · score 0.37
- systemic lupus erythematosus · score 0.27
- high density lipoprotein cholesterol measurement · score 0.25
- ovarian cancer · score 0.23
- genetic disorder · score 0.19
- lung adenocarcinoma · score 0.18
- melanoma · score 0.16
- ovarian carcinoma · score 0.16
- pancreatic carcinoma · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UMW8-F1 | alphafold | PREDICTED | 83.45 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UMW8.
Amino-acid sequence (372 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with USP18?
The strongest Open Targets associations for USP18 are Congenital intrauterine infection-like syndrome, pseudo-TORCH syndrome, systemic lupus erythematosus, high density lipoprotein cholesterol measurement and ovarian cancer.
How long is the USP18 protein?
The Homo sapiens USP18 protein (UniProt Q9UMW8) is 372 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UMW8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UMW8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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