Suppressor of fused homolog (SUFU)
Homo sapiens — UniProt Q9UMX1
Data last refreshed: (UniProt release unknown)
Key facts
Suppressor of fused homolog (SUFU) is a protein from Homo sapiens identified by UniProt accession Q9UMX1, 484 residues long. MolForge cross-references it against 0 known binders and 488 disease associations.
- UniProt accession: Q9UMX1; gene symbol SUFU.
- Organism: Homo sapiens.
- Length: 484 amino acids.
- Top disease associations (Open Targets): medulloblastoma, nevoid basal cell carcinoma syndrome and Joubert syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Suppressor of fused homolog |
|---|---|
| UniProt accession | Q9UMX1 |
| Gene | SUFU |
| Organism | Homo sapiens |
| Length | 484 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (488)
Diseases linked to this target (Open Targets).
- medulloblastoma · score 0.79
- nevoid basal cell carcinoma syndrome · score 0.74
- Joubert syndrome · score 0.72
- familial meningioma · score 0.65
- Inherited cancer-predisposing syndrome · score 0.55
- hereditary neoplastic syndrome · score 0.55
- meningioma · score 0.44
- skin basal cell carcinoma · score 0.38
- esophageal adenocarcinoma · score 0.37
- kidney neoplasm · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UMX1-F1 | alphafold | PREDICTED | 82.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UMX1.
Amino-acid sequence (484 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SUFU?
The strongest Open Targets associations for SUFU are medulloblastoma, nevoid basal cell carcinoma syndrome, Joubert syndrome, familial meningioma and Inherited cancer-predisposing syndrome.
How long is the SUFU protein?
The Homo sapiens SUFU protein (UniProt Q9UMX1) is 484 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UMX1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UMX1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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